The 3-hydroxypropanoate cycle has been found in species from the Archaeal order Sulfolobaceae and the bacteria Chloroflexus auruntiacus.
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EC 1.1.1.298 3-hydroxypropionate dehydrogenase (NADP+)
EC 1.2.1.75 malonyl CoA reductase (malonate semialdehyde-forming)
EC 1.3.1.84 acrylyl-CoA reductase (NADPH)
EC 1.3.99.1 succinate dehydrogenase
EC 2.8.3.22 succinyl-CoA—L-malate CoA-transferase
EC 4.1.3.24 malyl-CoA lyase
EC 4.1.3.25 (S)-citramalyl-CoA lyase
EC 4.2.1.2 fumarate hydratase
EC 4.2.1.153 3-methylfumaryl-CoA hydratase
EC 4.2.1.116 3-hydroxypropionyl-CoA dehydratase
EC 4.2.1.148 2-methylfumaryl-CoA hydratase
EC 5.1.99.1 methylmalonyl-CoA epimerase
EC 5.4.1.3 2-methylfumaryl-CoA isomerase
EC 5.4.99.2 methylmalonyl-CoA mutase
EC 6.2.1.36 3-hydroxypropionyl-CoA synthase
EC 6.4.1.2 acetyl-CoA carboxylase
EC 6.4.1.3 propionyl-CoA carboxylase