IUBMB Enzyme Nomenclature


Accepted name: methylmalonyl-CoA mutase

Reaction: (R)-methylmalonyl-CoA = succinyl-CoA

For diagram of reaction click here (another example).

Other name(s): methylmalonyl-CoA CoA-carbonyl mutase; methylmalonyl coenzyme A mutase; methylmalonyl coenzyme A carbonylmutase; (S)-methylmalonyl-CoA mutase; (R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase [incorrect]

Systematic name: (R)-methylmalonyl-CoA CoA-carbonylmutase

Comments: Requires a cobamide coenzyme.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, UM-BBD, CAS registry number: 9023-90-9


1. Barker, H.A. Coenzyme B12-dependent mutases causing carbon chain rearrangements, in Boyer, P.D. (Ed.), The Enzymes, 3rd edn., vol. 6, Academic Press, New York, 1972, pp. 509-537.

[EC created 1961, modified 1983]

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