IUBMB Enzyme Nomenclature


Accepted name: 3-hydroxypropionyl-CoA synthase

Reaction: 3-hydroxypropanoate + ATP + CoA = 3-hydroxypropanoyl-CoA + AMP + diphosphate

For diagram of reaction click here (another example).

Glossary: 3-hydroxypropanoyl-CoA = 3-hydroxypropionyl-CoA

Other name(s): 3-hydroxypropionyl-CoA synthetase (AMP-forming); 3-hydroxypropionate—CoA ligase; hydroxypropionate:CoA ligase (AMP-forming)

Systematic name: hydroxypropanoate:CoA ligase (AMP-forming)

Comments: Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1,2]. The enzymes from Metallosphaera sedula and Sulfolobus tokodaii can also use propionate, acrylate, acetate, and butanoate as substrates [2], and are thus different from EC (propionate—CoA ligase), which does not accept acetate or butanoate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Berg, I.A., Kockelkorn, D., Buckel, W. and Fuchs, G. A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea. Science 318 (2007) 1782-1786. [PMID: 18079405]

2. Alber, B.E., Kung, J.W. and Fuchs, G. 3-Hydroxypropionyl-coenzyme A synthetase from Metallosphaera sedula, an enzyme involved in autotrophic CO2 fixation. J. Bacteriol. 190 (2008) 1383-1389. [PMID: 18165310]

[EC created 2009]

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