Reaction: (3S)-citramalyl-CoA = acetyl-CoA + pyruvate
For diagram of reaction click here.
Other name(s): citramalyl coenzyme A lyase; (+)-CMA-CoA lyase; (3S)-citramalyl-CoA pyruvate-lyase; Mcl (ambiguous); citramalyl-CoA lyase
Systematic name: (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
Comments: Requires Mg2+ ions for activity . The enzyme from the bacterium Clostridium tetanomorphum is a component of EC 188.8.131.52, citramalate lyase . It also acts on (3S)-citramalyl thioacyl-carrier protein . The enzyme from the bacterium Chloroflexus aurantiacus also has the activity of EC 184.108.40.206, malyl-CoA lyase . It has no activity with (3R)-citramalyl-CoA (cf. EC 220.127.116.11, (R)-citramalyl-CoA lyase) .
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37290-68-9
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