IUBMB Enzyme Nomenclature


Accepted name: (S)-citramalyl-CoA lyase

Reaction: (3S)-citramalyl-CoA = acetyl-CoA + pyruvate

For diagram of reaction click here.

Other name(s): citramalyl coenzyme A lyase; (+)-CMA-CoA lyase; (3S)-citramalyl-CoA pyruvate-lyase; Mcl (ambiguous); citramalyl-CoA lyase

Systematic name: (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)

Comments: Requires Mg2+ ions for activity [3]. The enzyme from the bacterium Clostridium tetanomorphum is a component of EC, citramalate lyase [2]. It also acts on (3S)-citramalyl thioacyl-carrier protein [2]. The enzyme from the bacterium Chloroflexus aurantiacus also has the activity of EC, malyl-CoA lyase [3]. It has no activity with (3R)-citramalyl-CoA (cf. EC, (R)-citramalyl-CoA lyase) [3].

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37290-68-9


1. Cooper, R.A. and Kornberg, H.L. The utilization of itaconate by Pseudomonas sp. Biochem. J. 91 (1964) 82-91. [PMID: 4284209]

2. Dimroth, P., Buckel, W., Loyal, R. and Eggerer, H. Isolation and function of the subunits of citramalate lyase and formation of hybrids with the subunits of citrate lyase. Eur. J. Biochem. 80 (1977) 469-477. [PMID: 923590]

3. Friedmann, S., Alber, B.E. and Fuchs, G. Properties of R-citramalyl-coenzyme A lyase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus. J. Bacteriol. 189 (2007) 2906-2914. [PMID: 17259315]

[EC created 1972, modified 2014]

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