IUBMB Enzyme Nomenclature


Accepted name: 2-methylfumaryl-CoA isomerase

Reaction: 2-methylfumaryl-CoA = 3-methylfumaryl-CoA

For diagram of reaction click here.

Glossary: 2-methylfumaryl-CoA = (E)-3-carboxy-2-methylprop-2-enoyl-CoA
3-methylfumaryl-CoA = (E)-3-carboxybut-2-enoyl-CoA

Other name(s): mesaconyl-CoA C1-C4 CoA transferase; Mct

Systematic name: 2-methylfumaryl-CoA 1,4-CoA-mutase

Comments: The enzyme, purified from the bacterium Chloroflexus aurantiacus, acts as an intramolecular CoA transferase and does not transfer CoA to free mesaconate. It is part of the 3-hydroxypropanoate cycle for carbon assimilation.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Zarzycki, J., Brecht, V., Muller, M. and Fuchs, G. Identifying the missing steps of the autotrophic 3-hydroxypropionate CO2 fixation cycle in Chloroflexus aurantiacus. Proc. Natl. Acad. Sci. USA 106 (2009) 21317-21322. [PMID: 19955419]

[EC created 2014]

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