IUBMB Enzyme Nomenclature


Accepted name: ent-isokaurene synthase

Reaction: ent-copalyl diphosphate = ent-isokaurene + diphosphate

For diagram of reaction click here and mechanism click here.

Other name(s): OsKSL5i; OsKSL6

Systematic name: ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-isokaurene-forming)

Comments: Two enzymes of the rice sub-species Oryza sativa ssp. indica, OsKSL5 and OsKSL6, produce ent-isokaurene. A variant of OsKSL5 from the sub-species Oryza sativa ssp. japonica produces ent-pimara-8(14),15-diene instead [cf. EC, ent-pimara-8(14),15-diene synthase].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Xu, M., Wilderman, P.R., Morrone, D., Xu, J., Roy, A., Margis-Pinheiro, M., Upadhyaya, N.M., Coates, R.M. and Peters, R.J. Functional characterization of the rice kaurene synthase-like gene family. Phytochemistry 68 (2007) 312-326. [PMID: 17141283]

2. Xu, M., Wilderman, P.R. and Peters, R.J. Following evolution’s lead to a single residue switch for diterpene synthase product outcome. Proc. Natl. Acad. Sci. USA 104 (2007) 7397-7401. [PMID: 17456599]

[EC created 2012]

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