IUBMB Enzyme Nomenclature


Accepted name: sclareol synthase

Reaction: (13E)-8α-hydroxylabd-13-en-15-yl diphosphate + H2O = sclareol + diphosphate

For diagram of reaction click here

Glossary: sclareol = (13R)-labd-14-ene-8α,13-diol
(13E)-8α-hydroxylabd-13-en-15-yl diphosphate = 8-hydroxycopalyl diphosphate

Other name(s): SS

Systematic name: (13E)-8α-hydroxylabd-13-en-15-yl-diphosphate-lyase (sclareol forming)

Comments: Isolated from the plant Salvia sclarea (clary sage). Originally thought to be synthesized in one step from geranylgeranyl diphosphate it is now known to require two enzymes, EC, copal-8-ol diphosphate synthase and EC, sclareol synthase. Sclareol is used in perfumery.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Caniard, A., Zerbe, P., Legrand, S., Cohade, A., Valot, N., Magnard, J.L., Bohlmann, J. and Legendre, L. Discovery and functional characterization of two diterpene synthases for sclareol biosynthesis in Salvia sclarea (L.) and their relevance for perfume manufacture. BMC Plant Biol. 12 (2012) 119. [PMID: 22834731]

[EC created 2013, modified 2017]

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