IUBMB Enzyme Nomenclature


Accepted name: cembrene C synthase

Reaction: geranylgeranyl diphosphate = cembrene C + diphosphate

For diagram of reaction click here.

Glossary: cembrene C = (1E,5E,9E)-1,5,9-trimethyl-12-(propan-2-ylidene)cyclotetradeca-1,5,9-triene

Other name(s): DtcycA (gene name)

Systematic name: geranylgeranyl-diphosphate diphosphate-lyase (cembrene-C-forming)

Comments: Requires Mg2+. Isolated from the bacterium Streptomyces sp. SANK 60404. This bifunctional enzyme also produces (R)-nephthenol. See EC, nephthenol synthase.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Meguro, A., Tomita, T., Nishiyama, M. and Kuzuyama, T. Identification and characterization of bacterial diterpene cyclases that synthesize the cembrane skeleton. Chembiochem 14 (2013) 316-321. [PMID: 23386483]

[EC created 2014]

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