IUBMB Enzyme Nomenclature


Accepted name: nephthenol synthase

Reaction: geranylgeranyl diphosphate + H2O = (R)-nephthenol + diphosphate

For diagram of reaction click here.

Glossary: (R)-nephthenol = 2-[(1R,3E,7E,11E)-4,8,12-trimethyltetradeca-3,7,11-trien-1-yl]propan-2-ol

Other name(s): DtcycA (gene name); DtcycB (gene name)

Systematic name: geranylgeranyl-diphosphate diphosphate-lyase [(R)-nephthenol-forming]

Comments: Requires Mg2+. Two isozymes with this activity were isolated from the bacterium Streptomyces sp. SANK 60404. The enzyme encoded by the DtcycA gene also produces cembrene C (see EC, cembrene C synthase), while the enzyme encoded by the DtcycB gene also produces (R)-cembrene A and (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol (see EC, cembrene A synthase, and EC, pentamethylcyclopentadecatrienol synthase).

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Meguro, A., Tomita, T., Nishiyama, M. and Kuzuyama, T. Identification and characterization of bacterial diterpene cyclases that synthesize the cembrane skeleton. Chembiochem 14 (2013) 316-321. [PMID: 23386483]

[EC created 2014]

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