IUBMB Enzyme Nomenclature


Accepted name: cembrene A synthase

Reaction: geranylgeranyl diphosphate = (R)-cembrene A + diphosphate

For diagram of reaction click here.

Glossary: cembrene A = (1E,5E,9E,12R)-1,5,9-trimethyl-12-(propan-2-en-2-yl)cyclotetradeca-1,5,9-triene

Other name(s): DtcycB (gene name)

Systematic name: geranylgeranyl-diphosphate diphosphate-lyase [(R)-cembrene-A-forming]

Comments: Requires Mg2+. Isolated from the bacterium Streptomyces sp. SANK 60404. This trifunctional enzyme, which contains a [4Fe-4S] cluster, also produces (R)-nephthenol and (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol. See EC, nephthenol synthase and EC, pentamethylcyclopentadecatrienol synthase.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Meguro, A., Tomita, T., Nishiyama, M. and Kuzuyama, T. Identification and characterization of bacterial diterpene cyclases that synthesize the cembrane skeleton. Chembiochem 14 (2013) 316-321. [PMID: 23386483]

[EC created 2014]

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