EC 4.2.3.173

Reaction: (2E,6E)-farnesyl diphosphate + H₂O = τ-cadinol + diphosphate

For diagram of reaction click here

Glossary: τ-cadinol = 10β-cadin-4-en-10-ol

Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, τ-cadinol-forming)

Comments: Isolated from the plant Inula hupehensis. The enzyme also gives 10-epi-juneol and traces of other terpenoids, see EC 4.2.3.172, 10-epi-juneol synthase. It has also been isolated from the plants maize (Zea mays) and lavender (Lavandula angustifolia).

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. Gou, J.B., Li, Z.Q., Li, C.F., Chen, F.F., Lv, S.Y. and Zhang, Y.S. Molecular cloning and functional analysis of a 10-epi-junenol synthase from Inula hupehensis. Plant Physiol. Biochem. 106 (2016) 288-294. [PMID: 27231873]

2. Jullien, F., Moja, S., Bony, A., Legrand, S., Petit, C., Benabdelkader, T., Poirot, K., Fiorucci, S., Guitton, Y., Nicole, F., Baudino, S. and Magnard, J.L. Isolation and functional characterization of a τ-cadinol synthase, a new sesquiterpene synthase from Lavandula angustifolia. Plant Mol. Biol. 84 (2014) 227-241. [PMID: 24078339]

3. Ren, F., Mao, H., Liang, J., Liu, J., Shu, K. and Wang, Q. Functional characterization of ZmTPS7 reveals a maize τ-cadinol synthase involved in stress response. Planta 244 (2016) 1065-1074. [PMID: 27421723]