Reaction: ent-copalyl diphosphate = ent-atiserene + diphosphate
For diagram of reaction click here and mechanism click here
Other name(s): IrKSL4
Systematic name: ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-atiserine-forming)
Comments: Isolated from the plant Isodon rubescens and several species of Aconitum as well as species of Streptomyces.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Smanski, M.J., Yu, Z., Casper, J., Lin, S., Peterson, R.M., Chen, Y., Wendt-Pienkowski, E., Rajski, S.R. and Shen, B. Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis. Proc. Natl. Acad. Sci. USA 108 (2011) 13498Ð13503. [PMID: 21825154]
2. Jin, B., Cui, G., Guo, J., Tang, J., Duan, L., Lin, H., Shen, Y., Chen, T., Zhang, H. and Huang, L. Functional diversification of kaurene synthase-like genes in Isodon rubescens. Plant Physiol. 174 (2017) 943-955. [PMID: 28381502]
3. Tian, M., Jin, B., Chen, L., Ma, R., Ma, Q., Li, X., Chen, T., Guo, J., Ge, H., Zhao, X., Lai, C., Tang, J., Cui, G. and Huang, L. Functional diversity of diterpene synthases in Aconitum plants. Plant Physiol. Biochem. 202 (2023) 107968. [PMID: 37619270]