IUBMB Enzyme Nomenclature


Accepted name: aphidicolan-16β-ol synthase

Reaction: 9α-copalyl diphosphate + H2O = aphidicolan-16β-ol + diphosphate

For reaction pathway click here and mechanism click here.

Other name(s): PbACS

Systematic name: 9α-copalyl-diphosphate diphosphate-lyase (aphidicolan-16β-ol-forming)

Comment: This is a bifunctional enzyme which also has EC syn-copalyl diphosphate synthase activity. Aphidicolan-16β-ol is a precursor of aphidicolin, a specific inhibitor of DNA polymerase α (EC

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Oikawa, H., Toyomasu, T., Toshima, H., Ohashi, S., Kawaide, H., Kamiya, Y., Ohtsuka, M., Shinoda, S., Mitsuhashi, W. and Sassa, T. Cloning and functional expression of cDNA encoding aphidicolan-16 β-ol synthase: a key enzyme responsible for formation of an unusual diterpene skeleton in biosynthesis of aphidicolin. J. Am. Chem. Soc. 123 (2001) 5154-5155. [PMID: 11457369]

2. Toyomasu, T., Nakaminami, K., Toshima, H., Mie, T., Watanabe, K., Ito, H., Matsui, H., Mitsuhashi, W., Sassa T. and Oikawa, H. Cloning of a gene cluster responsible for the biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase α. Biosci. Biotechnol. Biochem. 68 (2004) 146-152. [PMID: 14745177]

[EC created 2009]

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