IUBMB Enzyme Nomenclature


Accepted name: β-santalene synthase

Reaction: (2E,6E)-farnesyl diphosphate = (–)-β-santalene + diphosphate

For diagram of reaction click here and mechanism click here.

Glossary: (–)-exo-α-bergamotene = (–)-trans-α-bergamotene = (1S,5S,6R)-2,6-dimethyl-6-(4-methylpent-3-en-1-yl)bicyclo[3.1.1]hept-2-ene

Systematic name: (2E,6E)-farnesyl-diphosphate lyase (cyclizing, (–)-β-santalene-forming)

Comments: The enzyme synthesizes a mixture of sesquiterpenoids from (2E,6E)-farnesyl diphosphate. As well as (–)-β-santalene (+)-α-santalene and (–)-exo-α-bergamotene are formed with traces of (+)-epi-β-santalene. See EC [(+)-α-santalene synthase], and EC [(–)-exo-α-bergamotene synthase].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Jones, C.G., Moniodis, J., Zulak, K.G., Scaffidi, A., Plummer, J.A., Ghisalberti, E.L., Barbour, E.L. and Bohlmann, J. Sandalwood fragrance biosynthesis involves sesquiterpene synthases of both the terpene synthase (TPS)-a and TPS-b subfamilies, including santalene synthases. J. Biol. Chem. 286 (2011) 17445-17454. [PMID: 21454632]

[EC created 2011]

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