IUBMB Enzyme Nomenclature


Accepted name: holocytochrome-c synthase

Reaction: holocytochrome c = apocytochrome c + heme

Other name(s): cytochrome c heme-lyase; holocytochrome c synthetase; holocytochrome-c apocytochrome-c-lyase

Systematic name: holocytochrome-c apocytochrome-c-lyase (heme-forming)

Comments: In the reverse direction, the enzyme catalyses the attachment of heme to two cysteine residues in the protein, forming thioether links.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 75139-03-6


1. Dumont, M.E., Ernst, J.F., Hampsey, D.M. and Sherman, F. Identification and sequence of the gene encoding cytochrome c heme lyase in the yeast Saccharomyces cerevisiae. EMBO J. 6 (1987) 235-241. [PMID: 3034577]

[EC created 1990]

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