IUBMB Enzyme Nomenclature


Accepted name: phosphosulfolactate synthase

Reaction: (2R)-2-O-phospho-3-sulfolactate = phosphoenolpyruvate + sulfite

For diagram of reaction click here (mechanism).

Glossary: bisulfite = HSO3

Other name(s): (2R)-phospho-3-sulfolactate synthase; (2R)-O-phospho-3-sulfolactate sulfo-lyase

Systematic name: (2R)-2-O-phospho-3-sulfolactate hydrogen-sulfite-lyase (phosphoenolpyruvate-forming)

Comments: Requires Mg2+. The enzyme from the archaeon Methanococcus jannaschii catalyses the Michael addition of sulfite to phosphoenolpyruvate. It specifically requires phosphoenolpyruvate and its broad alkaline pH optimum suggests that it uses sulfite rather than hydrogensulfite.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 473575-53-0


1. Graham, D.E., Xu, H. and White, R.H. Identification of coenzyme M biosynthetic phosphosulfolactate synthase: a new family of sulfonate-biosynthesizing enzymes. J. Biol. Chem. 277 (2002) 13421-13429. [PMID: 11830598]

[EC created 2003]

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