IUBMB Enzyme Nomenclature


Accepted name: olivetolic acid cyclase

Reaction: 3,5,7-trioxododecanoyl-CoA = CoA + 2,4-dihydroxy-6-pentylbenzoate

For diagram of reaction click here.

Glossary: 2,4-dihydroxy-6-pentylbenzoate = olivetolate

Other name(s): OAC

Systematic name: 3,5,7-trioxododecanoyl-CoA CoA-lyase (olivetolate-forming)

Comments: Part of the cannabinoids biosynthetic pathway in the plant Cannabis sativa.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Gagne, S.J., Stout, J.M., Liu, E., Boubakir, Z., Clark, S.M. and Page, J.E. Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides. Proc. Natl. Acad. Sci. USA 109 (2012) 12811-12816. [PMID: 22802619]

[EC created 2012]

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