IUBMB Enzyme Nomenclature


Accepted name: (2S)-3-sulfopropanediol sulfolyase

Reaction: (2S)-2,3-dihydroxypropane-1-sulfonate = hydroxyacetone + sulfite

Glossary: (2S)-2,3-dihydroxypropane-1-sulfonate = (2S)-3-sulfopropanediol

Other name(s): DHPS sulfolyase; hpsG (gene name)

Systematic name: (2S)-2,3-dihydroxypropane-1-sulfonate sulfite-lyase

Comments: The enzyme, characterized from the human gut bacterium Bilophila wadsworthia, contains a glycyl radical that is generated by a dedicated activating enzyme via chemistry involving S-adenosyl-L-methionine (AdoMet) and a [4Fe-4S] cluster.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Liu, J., Wei, Y., Lin, L., Teng, L., Yin, J., Lu, Q., Chen, J., Zheng, Y., Li, Y., Xu, R., Zhai, W., Liu, Y., Liu, Y., Cao, P., Ang, E.L., Zhao, H., Yuchi, Z. and Zhang, Y. Two radical-dependent mechanisms for anaerobic degradation of the globally abundant organosulfur compound dihydroxypropanesulfonate. Proc. Natl. Acad. Sci. USA 117 (2020) 15599-15608. [PMID: 32571930]

[EC created 2021]

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