IUBMB Enzyme Nomenclature


Accepted name: L-3-cyanoalanine synthase

Reaction: L-cysteine + hydrogen cyanide = hydrogen sulfide + L-3-cyanoalanine

Other name(s): β-cyanoalanine synthase; β-cyanoalanine synthetase; β-cyano-L-alanine synthase; L-cysteine hydrogen-sulfide-lyase (adding HCN)

Systematic name: L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide; L-3-cyanoalanine-forming)

Comments: Contains pyridoxal phospate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9059-53-4


1. Akopyan, T.N., Braunstein, A.E. and Goryachenkova, E.V. β-Cyanoalanine synthase: purification and characterization. Proc. Natl. Acad. Sci. USA 72 (1975) 1617-1621. [PMID: 1055433]

2. Castric, P.A. and Conn, E.E. Formation of β-cyanoalanine by O-acetylserine sulfhydrylase. J. Bacteriol. 108 (1971) 132-136. [PMID: 5001194]

3. Hendrickson, H.R. The β-cyanoalanine synthase of blue lupine. Fed. Proc. 27 (1968) 593 only.

4. Hendrickson, H.R. and Conn, E.E. Cyanide metabolism in higher plants. IV. Purification and properties of the β-cyanoalanine synthase of blue lupine. J. Biol. Chem. 244 (1969) 2632-2640. [PMID: 5769995]

[EC created 1972, deleted 1976, reinstated 1978]

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