IUBMB Enzyme Nomenclature


Accepted name: succinate—CoA ligase (ADP-forming)

Reaction: ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

For diagram of reaction click here.

Other name(s): succinyl-CoA synthetase (ADP-forming); succinic thiokinase (ambiguous); succinate thiokinase (ambiguous); succinyl-CoA synthetase (ambiguous); succinyl coenzyme A synthetase (adenosine diphosphate-forming); succinyl coenzyme A synthetase (ambiguous); A-STK (adenin nucleotide-linked succinate thiokinase); STK (ambiguous); A-SCS

Systematic name: succinate:CoA ligase (ADP-forming)

Links to other databases: BRENDA, EAWAG-BBD, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9080-33-5


1. Hager, L.P. Succinyl CoA synthetase, in Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.), The Enzymes, 2nd edn., vol. 6, Academic Press, New York, 1962, pp. 387-399.

2. Kaufman, S. Studies on the mechanism of the reaction catalyzed by the phosphorylating enzyme. J. Biol. Chem. 216 (1955) 153-164.

3. Kaufman, S. and Alivasatos, S.G.A. Purification and properties of the phosphorylating enzyme from spinach. J. Biol. Chem. 216 (1955) 141-152.

[EC created 1961]

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