Reaction: ATP + (3R)-β-phenylalanine + CoA = AMP + diphosphate + (3R)-β-phenylalanine-CoA (overall reaction)
(1a) ATP + (3R)-β-phenylalanine = diphosphate + (3R)-β-phenylalanineadenylate
(1b) (3R)-β-phenylalanineadenylate + CoA = AMP + (3R)-β-phenylalanine-CoA-CoA
For diagram of reaction click here
Other name(s): N7525_006484; β-phenylalanyl coenzyme A ligase; TAAE16 (gene name)
Systematic name: (3R)-β-phenylalanine:CoA ligase (AMP-forming)
Comments: The enzyme, characterized from the fungus Penicillium chrysogenum, acts on (3R)-β-phenylalanine and has slight activity on some other amino acids including (3S)-β-phenylalanine. It also acts on medium-chain-length alkanoic acids as EC 6.2.1.2 (medium-chain acyl-CoA ligase). In taxol-producing trees the enzyme is involved in taxol biosynthesis.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Koetsier, M.J., Jekel, P.A., Wijma, H.J., Bovenberg, R.A. and Janssen, D.B. Aminoacyl-coenzyme A synthesis catalyzed by a CoA ligase from Penicillium chrysogenum. FEBS Lett. 585 (2011) 893-898. [PMID: 21334330]