IUBMB Enzyme Nomenclature


Accepted name: D-alanine—D-alanine ligase

Reaction: ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine

For diagram click here.

Other name(s): MurE synthetase [ambiguous]; alanine:alanine ligase (ADP-forming); alanylalanine synthetase

Systematic name: D-alanine:D-alanine ligase (ADP-forming)

Comments: Involved with EC (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase) or EC (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—2,6-diaminopimelate ligase), EC (UDP-N-acetylmuramate—L-alanine ligase), EC (UDP-N-acetylmuramoyl-L-alanine—D-glutamate ligase) and EC (UDP-N-acetylmuramoyl-tripeptide—D-alanyl-D-alanine ligase) in the synthesis of a cell-wall peptide (click here for diagram).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9023-63-6


1. Ito, E. and Strominger, J.L. Enzymatic synthesis of the peptide in bacterial uridine nucleotides. II. Enzymatic synthesis and addition of D-alanyl-D-alanine. J. Biol. Chem. 237 (1962) 2696-2703.

2. Neuhaus, F.C. Kinetic studies on D-Ala-D-Ala synthetase. Fed. Proc. 21 (1962) 229 only.

3. van Heijenoort, J. Recent advances in the formation of the bacterial peptidoglycan monomer unit. Nat. Prod. Rep. 18 (2001) 503-519. [PMID: 11699883]

[EC created 1961, modified 2002]

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