Peptidoglycan Biosynthesis (Part 1)
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© IUBMB 2002
When cursor points to a box further details will be displayed in a tooltip window. If you click on the box you will change to appropriate enzyme specification.
© IUBMB 2002
Notes.
1. meso-2,6-Diaminopimelate (2,6-diaminoheptanoate, A2pm) is added by EC 6.3.2.13 in Gram-negative and some Gram-positive organisms. Lysine is added by EC 6.3.2.7 in other Gram-positive organisms.
2. The enzyme EC 6.3.2.10 attaches D-Ala-D-Ala to the C-terminal residue whether it is lysine or diaminopimelate. Subsequent enzymes in the pathway act regardless of which of these residues is present in their substrates.
enzymes homepage.
UDP-N-acetylglucosamine biosynthesis
peptidoglycan biosynthesis (part 2)
EC 1.1.1.158 UDP-N-acetylmuramate dehydrogenase
EC 2.5.1.7 UDP-N-acetylglucosamine 1-carboxyvinyltransferase
EC 6.3.2.4 D-alanine—D-alanine ligase
EC 6.3.2.7 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase
EC 6.3.2.8 UDP-N-acetylmuramate—L-alanine ligase
EC 6.3.2.9 UDP-N-acetylmuramoylalanine—D-glutamate ligase
EC 6.3.2.10 UDP-N-acetylmuramoyl-tripeptide—D-alanyl-D-alanine ligase
EC 6.3.2.13 UDP-N-acetylmuramoylalanyl-D-glutamate—2,6-diaminopimelate ligase