Reaction: ATP + (R)-pantoate + β-alanine = ADP + phosphate + (R)-pantothenate
For diagram of reaction click here.
Glossary: (R)-pantoate = (2R)-2,4-dihydroxy-3,3-dimethylbutanoate
(R)-pantothenate = 3-[(2R)-2,4-dihydroxy-3,3-dimethylbutanamido]propanoate
Other name(s): pantothenate synthetase (ambiguous); pantoateβ-alanine ligase (ambiguous)
Systematic name: (R)-pantoate:β-alanine ligase (ADP-forming)
Comments: The enzyme, characterized from the archaeon Methanosarcina mazei, is involved in the biosynthesis of pantothenate. It is different from EC 18.104.22.168, the AMP-forming pantoate-β-alanine ligase found in bacteria and eukaryota.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Ronconi, S., Jonczyk, R. and Genschel, U. A novel isoform of pantothenate synthetase in the Archaea. FEBS J. 275 (2008) 2754-2764. [PMID: 18422645]