IUBMB Enzyme Nomenclature


Accepted name: formate—dihydrofolate ligase

Reaction: ATP + formate + dihydrofolate = ADP + phosphate + 10-formyldihydrofolate

Other name(s): formyltransferase, dihydrofolate; dihydrofolate formyltransferase; formyl dihydrofolate synthase

Systematic name: formate:dihydrofolate ligase (ADP-forming)

Comments: Not identical with EC (formate—tetrahydrofolate ligase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 123303-25-3


1. Drake, J.C., Baram, J. and Allegra, C.J. Isolation and characterization of a novel dihydrofolate formylating enzyme from human MCF-7 breast cancer cells. Biochem. Pharmacol. 39 (1990) 615-618. [PMID: 2306274]

[EC created 1992]

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