Possible Mechanism of

EC 1.21.4.2 glycine reductase R = H
EC 1.21.4.3 sarcosine reductase R3 = H2,Me
EC 1.21.4.4 betaine reductase R = Me

© IUBMB 2003

The ammonia or methylamine generated may form a Schiff base with the pyruvoyl group shown either before or after cleavage of the C-N bond [See related mechanism for EC 1.21.4.1, D-proline reductase(dithiol)].

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EC 1.21.4.2 glycine reductase
EC 1.21.4.3 sarcosine reductase
EC 1.21.4.4 betaine reductase