Protoilludene and Related Sesquiterpenoids

Suggested mechanism of biosynthesis for pentalene based on Cane, D.E., Abell, C., Harrison, P.H., Hubbard, B.R., Kane, C.T., Lattman, R., Oliver, J.S. and Weiner, S.W. Terpenoid biosynthesis and the stereochemistry of enzyme-catalysed allylic addition-elimination reactions. Philos. Trans. R. Soc. Lond. B Biol. Sci. 332 (1991) 123-129. [PMID: 1678531] and Zu, L., Xu, M., Lodewyk, M.W., Cane, D.E., Peters, R.J. and Tantillo, D.J. Effect of isotopically sensitive branching on product distribution for pentalenene synthase: support for a mechanism predicted by quantum chemistry. J. Am. Chem. Soc. 134 (2012) 11369-113671. [PMID: 22738258]

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humulene derived sesquiterpenoids
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EC Δ6-protoilludene synthase
EC (2S,3R,6S,9S)-(–)-protoillud-7-ene synthase