Protoilludene and Related Sesquiterpenoids
Suggested mechanism of biosynthesis for pentalene based on Cane, D.E., Abell, C., Harrison, P.H., Hubbard, B.R., Kane, C.T., Lattman, R., Oliver, J.S. and Weiner, S.W. Terpenoid biosynthesis and the stereochemistry of enzyme-catalysed allylic addition-elimination reactions. Philos. Trans. R. Soc. Lond. B Biol. Sci. 332 (1991) 123-129. [PMID: 1678531] and Zu, L., Xu, M., Lodewyk, M.W., Cane, D.E., Peters, R.J. and Tantillo, D.J. Effect of isotopically sensitive branching on product distribution for pentalenene synthase: support for a mechanism predicted by quantum chemistry. J. Am. Chem. Soc. 134 (2012) 11369-113671. [PMID: 22738258]
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humulene derived sesquiterpenoids
EC 4.2.3.7 pentalenene synthase
EC 4.2.3.135 Δ6-protoilludene synthase
EC 4.2.3.160 (2S,3R,6S,9S)-(–)-protoillud-7-ene synthase