Mechanism of EC 5.4.3.8
Glutamate-1-semialdehyde 2,1-aminomutase

The scheme below rationalizes the reaction mechanism, see Smith, M.A., Kannangara, C.G. and Grimm, B. Glutamate 1-semialdehyde aminotransferase: anomalous enantiomeric reaction and enzyme mechanism. Biochemistry 31 (1992) 11249-11254. [PMID: 1445864] and Contestabile, R., Angelaccio, S., Maytum, R., Bossa, F. and John, R.A. The conformation of a conformationally mobile, active site loop to the reaction catalysed by glutamate semialdehyde aminomutase. J. Biol. Chem. 275 (2000) 3879-3886. [PMID: 10660540]

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EC 5.4.3.8 glutamate-1-semialdehyde 2,1-aminomutase