Porphyrin Biosynthesis (early stages)
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© IUBMB 2003
When cursor points to a box further details will be displayed in a tooltip window. If you click on the box you will change to appropriate reaction scheme or enzyme specification.
© IUBMB 2003
In the reaction of EC 4.2.1.24, the substrate forms an imine with the amino group of a lysine residue of the enzyme.
In the absence of EC 4.2.1.75, which cyclizes hydroxymethylbilane with reversal of ring D, cyclization occurs spontaneously, without such reversal, forming uroporphyrinogen I.
enzymes homepage.
porphyrin biosynthesis (later stages)
corrin biosynthesis
EC 1.2.1.70 glutamate-tRNA reductase
EC 2.3.1.37 5-aminolevulinate synthase
EC 2.5.1.61 hydroxymethylbilane synthase
EC 4.2.1.24 porphobilinogen synthase
EC 4.2.1.75 uroporphyrinogen-III synthase (mechanism)
EC 5.4.3.8 glutamate-1-semialdehyde 2,1-aminomutase(mechanism)
EC 6.1.1.17 glutamate—tRNA ligase