Continued from properties of families 4-9
I.A. Nonselective
I.B. Water
I.C. Cations
I.D Anions
II.A. Sugars and polyols
II.B. Monocarboxylates
III.B. Amines, amides, and polyamines
VII.B. Proteins
| Substrate | TC number | Family | Distributiona | Regulation |
| Nonselective | 1.A.17 | CSC | Pl | |
| 1.A.24 | Connexin | An | ||
| 1.A.25 | Innexin | An | ||
| 1E.1-1.E.19 | Holin | B, phage | ||
| 1.C | all toxin-type poreforming proteins/peptides | B, A, E | ||
| 1.A.31 | Annexin | E | ||
| 1.D.5 | Alamethicin | E | ||
| 1.D.7 | Beticolin | Fu | ||
| 1.D.8 | Saponin | Pl | ||
| Nonselective (slight cation-over-anion selectivity) | 1.A.22 | MscL | B | mechanosensitive (osmotic pressure) |
| Nonselective (slight anion-over-cation selectivity) | 1.A.23 | MscS | B | mechanosensitive (osmotic pressure) |
| Water | 1.A.8 | MIP aquaporins | B, E | hormonal regulation in An |
| 1.A.44 | UT | An |
| Cation-selective | 1.A.1.11 | VIC | An | voltage-sensitive |
| 1.A.3.1 | RIR-CaC | An | ryanodine-sensitive | |
| 1.A.3.2 | ROR-Ca | An | inositol-trisphosphate-sensitive | |
| 1.A.4 | TRP-CC | An | responsive to pain, heat, etc. | |
| 1.A.5 | PCC | An | Ca2+-activated | |
| 1.A.6.1.2 | EnaC | | proton-gated | | |
| 1.A.6.2.1 | EnaC | An | ||
| 1.A.7 | ACC | An | exogenous-ATP-sensitive | |
| 1.A.9.1 | LIC | An | acetylcholine-activated | |
| 1.A.9.2 | LIC | An | serotonin- activated | |
| 1.A.10.1.3 | GIC | An | glutamate-sensitive | |
| 1.A.14 | NSCC1 | An | ||
| 1.A.15 | NSCC2 | Fu, An | ||
| 1.A.16 | Mid1 | Y | stretch-activated | |
| 1.A.26 | SAT | Pl | ||
| 1.C.58 | Microcin E492 | B | ||
| 1.D.1 | Gramicidin A | B | ||
| 1.D.2 | Syringomycin | B | ||
| 1.D.3 | Syringopeptin | B | ||
| 1.D.4 | Tolaasin | B | ||
| H+ | 1.A.19 | IVC | An, V | |
| 1.A.20 | CybB | An, Pl | arachidonate | |
| 1.A.30.1 | Mot | B | ||
| 1.A.45 | Mot | B | ||
| K+ | 1.A.1.1-9 | VIC | B, A, E | voltage-sensitive; Ca2+-activated; cyclic-nucleotide-gated |
| 1.A.2 | IRK-C | An | ATP-regulated; G-protein-regulated; voltage-sensitive | |
| Na+ | 1.A.1.10 | VIC | An | voltage-sensitive |
| 1.A.6.1.1 | ENaC | An | ligand-regulated | |
| 1.A.6.3.1 | EnaC | An | peptide-regulated | |
| 1.A.30.1 | Mot | B | ||
| Na+, K+, (Ca2+) selective | 1.A.10 | GIC | An | glutamate-gated |
| NH4+ | 1.A.26 | SAT | Pl | |
| Heavy-metal ions | 1.A.35 | Amoebapore | B |
| Cl- | 1.A.9.3 | LIC | An | glycine-inhibited |
| 1.A.9.4 | LIC | An | glutamate-inhibited | |
| 1.A.9.5 | LIC | An | g-aminobutyrate-inhibited | |
| 1.A.12 | O-ClC | An | voltage-regulated | |
| 1.A.13 | E-ClC | An; B? | Ca2+-calmodulin- kinase-regulated | |
| Cl- (anion-selective) | 1.A.11 | ClC | B, A, E | voltage-regulated |
| 1.A.16 | Tic110 | Pl | ||
| 1.A.27 | PLM | An | hyperpolarization-activated | |
| 1.A.36 | ICC | E |
| Glycerol | 1.A.8 | MIP-glycerol | B, E | glycerol-inducible in bacteria |
| 1,2-Propanediol | 1.A.8 | MIP-glycerol | B, E | glycerol-inducible in bacteria |
| Organic anions | 1.A.27 | PLM | An | hyperpolarization-activated |
| Gluconate | 1.A.27 | PLM | An | hyperpolarization-activated |
| Glutamate | 1.A.27 | PLM | An | hyperpolarization-activated |
| Isethionate | 1.A.27 | PLM | An | hyperpolarization-activated |
| Lactate | 1.A.27 | PLM | An | hyperpolarization-activated |
| Taurine | 1.A.27 | PLM | An | hyperpolarization-activated |
III.B. Amines, amides, and polyamines
| Methylammonium | 1.A.26 | SAT | Pl |
| Urea | 1.A.8 | MIP | B |
| 1.A.28 | UT | An | |
| Urea, amides | 1.A.29 | UAC | An |
| Endolysin | 1.E.1-1.E.17 | Holin | B, phages | |
| Botulinum toxin, L-chainb | 1.C.8.1.1 | BTT | B | |
| Cytochrome c | 1.A.21 | Bcl-2 | An | |
| Diphtheria toxin, A-chainb | 1.C.7.1.1 | DT | B | |
| Nucleases | 1.A.34.3 | Holin | B | |
| Proteins | 1.A.18 | Tic110 | Pl | |
| 1.A.33 | Hsp70 | A, B, E | ||
| RNA | 1.A.34 | EVE1-C | viruses | |
| Tetanus toxin, L-chainb | 1.C.8.1.2 | BTT | B | |
| Thioredoxin | 1.A.22.1.1 | MscL | B | osmotic downshift |
b These toxins in TC category 1.C function to import proteins into the host cell.