Classification of Transport Proteins According to Substrate Specificity

2. Outer Membrane Porins (most from Gram-negative bacteria)

Contents

I.A. Nonselective
I.C. Cations
I.D. Anions
II.A. Sugars and polyols
II.B. Monocarboxylates
II.E. Others
III.A. Amides
IV.B. Nucleosides
IV.C. Nucleotides
V.A. Vitamins
V.B. Enzyme and redox cofactors
V.C. Iron-siderophores
VI.A. Multiple drugs
VII.A. Carbohydrates
VII.B. Proteins

I.A. Nonselective

Substrate TC number Family

Nonselective 1.B.1, -2, -4, -6, -7,
-8, -21, -23-26 GBP, CP, BRP, OOP, RPP, MPP,
OmpG, CBP, MBP, Opr, CDP

Nonselective (slight
cation selectivity) 1.B.15.1.1 RafY

I.C. Cations

Fe³⁺- or Fe³⁺-chelate-selective 1.B.14.3.2 OMR

Metal ions 1.B.17.2.1 OMF

I.D. Anions

Anion-selective 1.B.1.6.1 GBP

1.B.8 MPP

1.B.13 AEP

Phosphate-selective 1.B.1.1.2 GBP

1.B.5.1.1 POP

Diphosphate-selective 1.B.5.1.2 POP

II.A. Sugars and polyols

Glucose 1.B.19.1.1 OprB

Maltooligosaccharide-selective 1.B.3.1.1 SP

Oligosaccharide-selective 1.B.3.1.2 SP

II.B. Monocarboxylates

Fatty-acid-selective 1.B.9.1.1 FadL

II.E. Others

Toluene-selective 1.B.9.2.1 FadL

III.A. Amides

Amides, short chain 1.B.16.1.1 SAP

Urea 1.B.16.1.1 SAP

IV.B. Nucleosides

Nucleoside-selective 1.B.10.1.1 Tsx

IV.C. Nucleotides

Nucleotide-selective 1.B.1.1.4 GBP

V.A. Vitamins

Cobalamin-selective 1.B.14.3.1 OMR

V.B. Enzyme and redox cofactors

Heme 1.B.14.2.3 OMR

Porphyrin 1.B.14.3.1 OMR

V.C. Iron-siderophores

Iron-complex-selective 1.B.14.1.1-4;
1.B.14.2-3 OMR

Fe³⁺-catecholate 1.B.14.3.2 OMR

Fe³⁺-citrate 1.B.14.1.2 OMR

Fe³⁺-coprogen 1.B.14.1.3 OMR

Fe³⁺-enterobactin 1.B.14.1.1 OMR

Ferrichrome 1.B.14.1.4 OMR

Heme 1.B.14.2.3 OMR

1.B.20.3.1 TEC

VI.A. Multiple drugs

Drug (multiple)-selective 1.B.17.1.1 OMF

1.B.17.3.2 OMF

1.B.17.3.3 OMF

VII.A. Carbohydrates

Alginate (acidic polysaccharide) 1.B.13.1.1 AEP

Capsular- or
exopolysaccharide-selective 1.B.18.1.1-2;
1.B.18.2.1 OMA

Lipooligosaccharide-selective 1.B.17.3.1 OMF

Polymannonate 1.B.13.1.1 AEP

Polysaccharide-selective 1.B.13.1.1 AEP

VII.B. Proteins

Albomycin 1.B.14.1.4 OMR

Colicin I-selective 1.B.14.3.2 OMR

Colicin M-selective 1.B.14.1.4 OMR

Colicin B-selective 1.B.14.1.1 OMR

Colicin D-selective 1.B.14.1.1 OMR

Fimbrial-subunit-selective 1.B.11.1-3 FUP

Hemin-selective 1.B.14.2.3 OMR

Hemoglobin-selective 1.B.14.2.2 OMR

Protein (virulence factor)-selective 1.B.12 AT

Protein (hemolysin)-selective 1.B.17.1.1 OMF

1.B.20.1.2 TEC

Protein (hemagglutinin)-selective 1.B.20.2.1 TEC

Protein (protease)-selective 1.B.17.1.2 OMF

Protein (cyclolysin)-selective 1.B.17.2.3 OMF

Protein (toxin)-selective 1.B.20.1.1 TEC

Transferrin-selective 1.B.14.2.1 OMR

Protein (competence factor)-selective 1.B.22.1.6 Secretin

Protein (secretory protein)-selective 1.B.22.1.1 Secretin

Protein (fimbrial subunit)-selective 1.B.22.1.3 Secretin

Protein (virulence factor)-selective 1.B.22.1.2;
1.B.22.1.4;
1.B.22.1.5 Secretin

Protein (phage)-selective 1.B.22.1.7 Secretin

Continued with Class 3
Return to Membrane Transport Proteins home page
Return to Biochemical Nomenclature home page

Substrate	TC number	Family
Nonselective	1.B.1, -2, -4, -6, -7, -8, -21, -23-26	GBP, CP, BRP, OOP, RPP, MPP, OmpG, CBP, MBP, Opr, CDP
Nonselective (slight cation selectivity)	1.B.15.1.1	RafY

Fe³⁺- or Fe³⁺-chelate-selective	1.B.14.3.2	OMR
Metal ions	1.B.17.2.1	OMF

Anion-selective	1.B.1.6.1	GBP
	1.B.8	MPP
	1.B.13	AEP
Phosphate-selective	1.B.1.1.2	GBP
Phosphate-selective	1.B.5.1.1	POP
Diphosphate-selective	1.B.5.1.2	POP

Glucose	1.B.19.1.1	OprB
Maltooligosaccharide-selective	1.B.3.1.1	SP
Oligosaccharide-selective	1.B.3.1.2	SP

Iron-complex-selective	1.B.14.1.1-4; 1.B.14.2-3	OMR
Fe³⁺-catecholate	1.B.14.3.2	OMR
Fe³⁺-citrate	1.B.14.1.2	OMR
Fe³⁺-coprogen	1.B.14.1.3	OMR
Fe³⁺-enterobactin	1.B.14.1.1	OMR
Ferrichrome	1.B.14.1.4	OMR
Heme	1.B.14.2.3	OMR
Heme	1.B.20.3.1	TEC

Drug (multiple)-selective	1.B.17.1.1	OMF
	1.B.17.3.2	OMF
	1.B.17.3.3	OMF

Alginate (acidic polysaccharide)	1.B.13.1.1	AEP
Capsular- or exopolysaccharide-selective	1.B.18.1.1-2; 1.B.18.2.1	OMA
Lipooligosaccharide-selective	1.B.17.3.1	OMF
Polymannonate	1.B.13.1.1	AEP
Polysaccharide-selective	1.B.13.1.1	AEP

Albomycin	1.B.14.1.4	OMR
Colicin I-selective	1.B.14.3.2	OMR
Colicin M-selective	1.B.14.1.4	OMR
Colicin B-selective	1.B.14.1.1	OMR
Colicin D-selective	1.B.14.1.1	OMR
Fimbrial-subunit-selective	1.B.11.1-3	FUP
Hemin-selective	1.B.14.2.3	OMR
Hemoglobin-selective	1.B.14.2.2	OMR
Protein (virulence factor)-selective	1.B.12	AT
Protein (hemolysin)-selective	1.B.17.1.1	OMF
Protein (hemolysin)-selective	1.B.20.1.2	TEC
Protein (hemagglutinin)-selective	1.B.20.2.1	TEC
Protein (protease)-selective	1.B.17.1.2	OMF
Protein (cyclolysin)-selective	1.B.17.2.3	OMF
Protein (toxin)-selective	1.B.20.1.1	TEC
Transferrin-selective	1.B.14.2.1	OMR
Protein (competence factor)-selective	1.B.22.1.6	Secretin
Protein (secretory protein)-selective	1.B.22.1.1	Secretin
Protein (fimbrial subunit)-selective	1.B.22.1.3	Secretin
Protein (virulence factor)-selective	1.B.22.1.2; 1.B.22.1.4; 1.B.22.1.5	Secretin
Protein (phage)-selective	1.B.22.1.7	Secretin