Classification of Membrane Transport Proteins

Continued from class 2

Classification of Transport Proteins According to Substrate Specificity

3. Uniporters, Symporters and Antiporters

Contents

I.C.1. Inorganic cations: univalent
I.C.2. Inorganic cations: di- and tervalent
I.D. Inorganic anions
II.A. Sugars and polyols
II.B. Monocarboxylates
II.C. Di- and tricarboxylates
II.D. Organic anions (noncarboxylates)
III.A. Amino acids and conjugates
III.B. Amines, amides, and polyamines
III.C. Peptides
IV.A. Nucleobases
IV.B. Nucleosides
IV.C. Nucleotides
V.A. Vitamins/cofactor precursors
V.B. Enzyme and redox cofactors
V.C. Siderophores and Fe-siderophore complexes
V.D. Signaling molecules
VI.A. Multiple drugs and dyes
VI.B. Specific drugs
VI.C. Bile salts and conjugates
VI.D. Sterols/steroids
VII.A. Carbohydrates
VII.B. Proteins
VII.D. Lipids

I.C. Inorganic cations: univalent

Substrate TC number Family Energy source or mechanism Distribution^a

Ag⁺ (efflux) 2.A.6.1.3 RND Ag⁺:H⁺ antiport B

H⁺ 2.A.33.1.1 NhaA H⁺:Na⁺ antiport B

2.A.34.1.1 NhaB H⁺:Na⁺ antiport B

2.A.35.1.1 NhaC H⁺:Na⁺ antiport B

2.A.36.1.3-5 CPA1 H⁺:Na⁺ antiport B, E

2.A.37.1-5 CPA2 H⁺:Na⁺ antiport B, Y

2.A.38.1-4 Trk H⁺,K⁺ symport B, Pl

2.A.62.1.1 NhaD H⁺:Na⁺ antiport B

2.A.63.1.1-3 CPA3 H⁺:Na⁺ or K⁺ antiport B

H⁺ or OH^- 2.A.29.3.1 MC uniport (?) Mito

K⁺ 2.A.19.3.2 CaCA K⁺,Ca²⁺ symport;
Na⁺ or H⁺ antiport An

2.A.30.1-3, -7 CCC Na⁺, Cl^- and K⁺, Cl^- symport An, Pl

2.A.30.5-6 CCC K⁺, Cl^- symport An

2.A.36.4.1 CPA1 K⁺:H⁺ antiport Y

2.A.37.1-5 CPA2 K⁺:H⁺ antiport B, Y

2.A.38.1-4 Trk cation uptake (PMF?);
K⁺, H⁺ or Na⁺ symport B, Pl

2.A.63.1.1 CPA3 K⁺:H⁺ antiport B

2.A.72.1-3 KUP K⁺ uptake
(K⁺,H⁺ or K⁺,Na⁺ symport) B, Y, Pl

2.A.30.1-3 CCC Na⁺, K⁺, 2Cl^- symport An

Na⁺ 2.A.30.4.1 CCC Na⁺, Cl^- symport An

2.A.30.7.1 CCC Na,K,Cl₂ symport Pl

2.A.33.1.1 NhaA Na⁺:H⁺ antiport B

2.A.34.1.1 NhaB Na⁺:H⁺ antiport B

2.A.35.1.1 NhaC Na⁺:H⁺ antiport B

2.A.36.1-4 CPA1 Na⁺:H⁺ antiport B, E

2.A.37.2.1 CPA2 Na⁺:H⁺ antiport B

2.A.38.3.1 Trk Na⁺,H⁺ symport Pl

2.A.62.1.1 NhaD Na⁺:H⁺ antiport B

2.A.63.1.2-3 CPA3 Na⁺:H⁺ antiport B

NH₃ or NH₄⁺ 2.A.49 Amt uniport? B, A, E

I.C.2. Inorganic cations: di- and tervalent

Al³⁺ 9.A.17.2.1 MIT uniport? Y

Ca²⁺ 2.A.19.1-4 CaCA H⁺ or Na⁺ antiport B, Y, Pl vacuoles, An

Cations, divalent; nonspecific 9.A.17.1-2 MIT uniport? B, Y

2.A.3.10.1 APC ? Y, Fu

2.A.5.1.2 ZIP PMF (uptake) Pl

2.A.55.1-2 Nramp H⁺ symport Y, An

Cd²⁺ 2.A.4.1.1 CDF PMF? (efflux) B

2.A.4.2.2 CDF PMF? (uptake) Mito

2.A.6.1.2 HME PMF (H⁺ antiport) B

2.A.77.1.1 CadD PMF (efflux) B

Co²⁺ 2.A.4.1.1-2 CDF PMF? (efflux) B

2.A.4.2.1 CDF PMF? (uptake) Mito

2.A.6.1.1-2 RND H⁺ antiport B

9.A.17.1.1 MIT PMF? (uptake) (uniport?) B

2.A.52.1.2 NiCoT PMF? (uptake) B

Cu²⁺ 9.A.11.1.1 Ctr1 PMF? (uptake) Y

9.A.12.1.1 Ctr2 PMF? (uptake) E

Fe²⁺ 2.A.5.1.2 ZIP PMF? E

9.A.17.1.1 MIT PMF? (uptake) B, A, Y

9.A.9.1.1 FeT PMF? (uptake) Y

Fe³⁺ 9.A.10.1.1 OfeT PMF? (uptake) B, Y

Hg²⁺ 9.A.2.1.1 MerTP PMF? (uptake) B

9.A.3.1.1 MerC PMF? (uptake) B

Mg²⁺ 2.A.11.1.1 CitMHS H⁺ symport B

9.A.17.1.1 MIT PMF? (uptake) B

9.A.19.1.1 MgtE ? B, A

Mn²⁺ 2.A.3.1.15 APC PMF? (efflux) Y

2.A.5.2.1 ZIP PMF (uptake) Y

2.A.19.2.2 CaCA PMF (H⁺ antiport) Y

9.A.17.2.2 MIT PMF? (efflux) Y

2.A.55.1.1-2 Nramp H⁺ symport (uptake) B, A, E

Ni²⁺ 2.A.1.21.5 MFS PMF? (efflux) B

2.A.6.1.1 RND H⁺ antiport B

9.A.17.1.1 MIT PMF? (uptake) B

2.A.52.1.1 NiCoT uniport? (uptake) B

Zn²⁺ 2.A.4.1.1-2 CDF PMF? (efflux) B

2.A.4.2.1-2 CDF PMF? (uptake) Mito

2.A.4.2.3 CDF PMF? (efflux) An

2.A.4.3.1 CDF PMF? (uptake) An vesicles

2.A.5.1.1 ZIP PMF? (uptake) E

2.A.6.1.2 RND H⁺ antiport B

I.D. Inorganic anions

Antimonite 2.A.45.1.1 ArsB PMF (efflux) B

Arsenite 2.A.45.1.1 ArsB PMF (efflux) B

2.A.59.1.1 ACR3 PMF (efflux) Y

Bicarbonate 2.A.31.1.1 AE anion antiport An, Y

2.A.31.2.1 AE Na⁺ symport An

2.A.73.1.1 ICT H⁺ symporter? B

Chlorate 2.A.17.3.1-3 POT H⁺ symport Pl

Chloride 2.A.30.1-3 CCC Na⁺,K⁺ symport An

2.A.30.4.1 CCC Na⁺ symport An

2.A.30.5-6 CCC K⁺ symport An

2.A.30.7.1 CCC Na⁺,K⁺ symport Pl

2.A.31.1.1 AE anion antiport An, Y

Chromate 2.A.51.1.1 CHR PMF (efflux) B

Cyanate 2.A.1.17.1 MFS H⁺ symport B

Inorganic anions (general) 2.A.31.1.1 AE anion antiport E

Inorganic univalent anions
(nonselective) 2.A.21.5.1 SSS Na⁺ symport An

Iodide 2.A.21.5.1 SSS Na⁺ symport An

Nitrate 2.A.1.8.2-6 MFS H⁺ symport B

2.A.17.3.1, -3 POT H⁺ symport Pl

Nitrite 2.A.1.8.1 MFS uniport; H⁺ symport? B

2.A.44.3.1 FNT H⁺ symport? B

Phosphate 2.A.1.4.1-4 MFS H⁺ symport?;
anion:anion antiport B

2.A.1.9.1-3 MFS H⁺ symport Y, Fu, Pl

2.A.1.14.6 MFS Na⁺ symport An

2.A.20.1-3 Pit H⁺ or Na⁺ symport B, A, Fu

2.A.29.4.1 MC OH^- antiport Mito

2.A.47.2.1 DASS H⁺ symport Y

2.A.58.1.1 PNaS Na⁺ symport B, An

Silicate 2.A.32.1.1 Sit Na⁺ symport diatoms

Sulfate 2.A.29.15.1 MC solute:solute antiport Y Mito

2.A.47.1.2 DASS Na⁺ symport An

2.A.53.1-4 SulP H⁺ symport or
HCO₃ antiport B, E

2.A.51.1.2 CHR H⁺ symport? B

Thiosulfate 2.A.29.15.1 MC solute:solute antiport Y Mito

Tellurite 2.A.16.1.1 TDT PMF (efflux) B

II.A. Sugars and polyols

Arabinitol 2.A.1.18.1 MFS H⁺ symport B

Arabinose 2.A.1.1.2 MFS H⁺ symport B

2.A.1.2.14-15 MFS H⁺ antiport B

Fructose 2.A.1.1.13 MFS H⁺ symport An

2.A.1.1.16 MFS uniport Pr

L-Fucose 2.A.1.7.1 MFS H⁺ symport B

Galactose 2.A.21.3.1-2 SSS Na⁺ symport B, An

2.A.1.1.1 MFS H⁺ symport B

2.A.1.1.2 MFS H⁺ symport B

2.A.11.6 MFS uniport Y

2.A.11.9 MFS H⁺ symport Y

2.A.17.2 MFS H⁺ symport B

Glucose 2.A.1.1.4 MFS uniport Y

2.A.1.1.6 MFS uniport Y

2.A.1.1.12 MFS uniport An

2.A.1.1.16 MFS uniport Pr

2.A.1.1.17 MFS ? Pr

2.A.1.7.2 MFS H⁺ symport B

2.A.1.7.3 MFS H⁺ symport B

2.A.9.2.1 RhaT H⁺ symport B

2.A.21.3.1 SSS Na⁺ symport An

2.A.21.3.1-4 SSS Na⁺ symport B, An

Glucose (sensor) 2.A.1.1.18-19 MFS ? Y

a-Glucosides 2.A.1.1.11 MFS H⁺ symport Y

Glucuronide 2.A.2.3.1 GPH H⁺ symport B

Hexoses 2.A.11.5 MFS uniport Y, An

2.A.1.1.14 MFS H⁺ symport Pl

2.A.1.1.16 MFS uniport Pr

Hexuronates 2.A.1.14.2 MFS H⁺ symport B

myo-Inositol 2.A.1.1.8 MFS H⁺ symport ?

2.A.1.1.20 MFS H⁺ symport Pr

2.A.21.4.1 SSS Na⁺ symport An

Isoprimeverose 2.A.2.3.3 GPH H⁺ symport B

Isopropyl-b-thiogalactoside
(efflux) 2.A.1.20.1, -4 MFS H⁺ antiport B

2.A.1.2.15, -18 MFS H⁺ antiport B

Lactose 2.A.1.1.9 MFS H⁺ symport Y

2.A.1.5.1 MFS H⁺ symport B

2.A.2.2.1 GPH H⁺ symport B

Lactose (efflux) 2.A.1.20.1-2
and 4 MFS H⁺ antiport B

Maltose 2.A.1.1.10 MFS H⁺ symport Y

Maltose (efflux) 2.A.1.20.1 MFS H⁺ antiport B

Mannose 2.A.1.1.16 MFS uniport Pr

2.A.1.7.3 MFS H⁺ symport B

Melibiose 2.A.1.5.4 MFS H⁺ symport B

2.A.2.1.1 GPH H⁺ or Na⁺ symport B

Melibiose (efflux) 2.A.1.2.18 MFS H⁺ antiport B

Multiple sugars 2.A.1.20 MFS H⁺ antiport ?

Pentosides 2.A.2.3.2-3 GPH H⁺ symport B

Raffinose 2.A.1.5.2 MFS H⁺ symport B

2.A.2.2.2 GPH H⁺ symport B

L-Rhamnose 2.A.9.1.1 RhaT H⁺ symport B

Ribitol 2.A.1.18.2 MFS H⁺ symport B

Ribose 2.A.9.3.1 RhaT H⁺ symport B

Sialic acid 2.A.1.12.1 MFS H⁺ symport B

Sucrose 2.A.1.5.3 MFS H⁺ symport B

2.A.2.4.1 GPH H⁺ symport Pl

Sugars (efflux), fairly
nonspecific 2.A.1.20.1-2, -4 MFS H⁺ antiport B

Xylose 2.A.1.1.2 MFS H⁺ symport B

2.A.1.1.3 MFS H⁺ symport B

II.B. Monocarboxylates

Acetate 2.A.44.4.1 FNT H⁺ symport Y

Allantoate 2.A.1.14.4 MFS H⁺ symport Y

Auxin (indole 3-acetate) 2.A.18.1.1 AAAP H⁺ symport Pl

Auxin (out) 2.A.69.1.1 AEC uniport? H⁺ antiport? Pl

Benzoate 2.A.1.15.5 MFS H⁺ symport B

2.A.46.1.1 BenE H⁺ symport B

Bile salts 2.A.1.3.13 MFS H⁺ symport B

2.A.6.2.5 RND H⁺ antiport B

2.A.28.1.1 BASS Na⁺ symport An

Bile salts (conjugated) 2.A.1.23.1 MFS H⁺ symport B

Bile salts (conjugated
and unconjugated) 2.A.60.1 OAT ? An

Bilirubin 2.A.65.1.1 BRT H⁺ symport? An

Cyanate 2.A.1.17.1 MFS H⁺ symport B

D-erythro-3-Deoxyhexulosonate ^b 2.A.10.1.1 KDGT H⁺ symport B

2,4-Dichlorophenoxyacetate 2.A.1.15.3 MFS H⁺ symport B

Digoxin 2.A.60.1.1 OAT uniport; anion antiport An

Fatty acids 2.A.6.2.5 RND H⁺ antiport B

Formate 2.A.1.11.1 MFS solute:solute antiport B

2.A.44.1.1 FNT B

2.A.44.2.1 FNT uptake? B

Galacturonate 2.A.1.14.2 MFS H⁺ symport B

Glucarate 2.A.1.14.1 MFS H⁺ symport B

Gluconate 2.A.8.1.1 GntP H⁺ symport B

2.A.8.1.2 GntP H⁺ symport B

Glucuronate 2.A.1.14.2 MFS H⁺ symport B

Hexuronate 2.A.1.14.2 MFS H⁺ symport B

4-Hydroxybenzoate 2.A.1.15.1 MFS H⁺ symport B

3-Hydroxyphenyl acetate 2.A.1.14.9 MFS H⁺ symport B

3-Hydroxyphenyl propionate 2.A.1.15.2 MFS H⁺ symport B

L-Idonate 2.A.8.1.2 GntP H⁺ symport B

Lactate 2.A.1.12.2 MFS H⁺ symport Y

2.A.1.13.1 MFS H⁺ symport Y, Fu, An

2.A.14.1.1 LctP H⁺ symport B

2.A.24.3.2 CCS solute:solute antiport B

Leucotrienes 2.A.60.1.7 OAT ? An

4-Methylphthalate 2.A.1.6.5 MFS H⁺ symport B

Mevalonate 2.A.1.13.1 MFS H⁺ symport Y, Fu, An

Monocarboxylates 2.A.1.13.1 MFS H⁺ symport Y, Fu, An

cis,cis-Muconate 2.A.1.15.4 MFS H⁺ symport B

Organic anions (nonselective) 2.A.1.19.4, -7-8 MFS H⁺ symport? An

2.A.21.5.2 SSS Na⁺ symport An

2.A.60.1 OAT uniport; anion antiport An

2.A.65.1.1 BRT H⁺ symport? An

Phenylpropionate 2.A.1.27.1 MFS H⁺ symport B

Phenylacetate 2.A.21.7.1 SSS H⁺ symport B

Phthalate 2.A.1.14.5 MFS H⁺ symport B

Prostaglandins 2.A.60.1.2, -7 OAT uniport; anion antiport An

Protocatechuate 2.A.1.15.1 MFS H⁺ symport B

Pyruvate 2.A.1.12.1 MFS H⁺ symport Y

2.A.1.13.1 MFS H⁺ symport Y, Fu, An

Quinate 2.A.1.1.7 MFS H⁺ symport Fu

Shikimate 2.A.1.6.6 MFS H⁺ symport B

Sialate 2.A.1.12.1 MFS H⁺ symport B

Tartrate 2.A.1.14.3 MFS H⁺ symport B

2.A.47.3.3 DASS solute:solute antiport B

Taurocholate 2.A.60.1.3, -7 OAT ? An

Thromboxanes 2.A.60.1.2, -7 OAT ? An

Thyroid hormones (thyroxin;
triiodothyronine) 2.A.60.1.3, -7 OAT ? An

II.C. Di- and tricarboxylates

Citrate 2.A.1.6.1 MFS H⁺ symport B

2.A.11.1.1 CitMHS Mg²⁺,H⁺ symport B

2.A.11.1.2 CitMHS H⁺ symport B

2.A.24.1.1;
-3.1, -3.2 CCS Na⁺ symport B

2.A.47.1.3, -3.2 DASS Na⁺ symport;
solute:solute antiport B, An

Dicarboxylates 2.A.1.6.3 MFS H⁺ symport B

2.A.13.1.1-2 Dcu solute:solute antiport B

2.A.16.2.1 TDT H⁺ symport Y

2.A.23.1.3 DAACS H⁺ symport B

2.A.29.2.1-2;
-13.1 MC solute:solute antiport Mito

2.A.47.1.1, -3 DASS Na⁺ symport An

2.A.47.3.1, -3 DASS solute:solute antiport B, Chloro

2.A.56.1.1 TRAP-T H⁺ symport B

2.A.61.1.1 DcuC H⁺ symport B

a-Ketoglutarate 2.A.1.6.2 MFS H⁺ symport B

Malate 2.A.16.2.1 TDT H⁺ symport? Y

2.A.24.2.1 CCS H⁺ symport B

2.A.69.3.1 AEC H⁺ symport? B

Malonate 2.A.29.15.1 MC solute:solute antiport Y Mito

2.A.69.2.1 AEC H⁺ symport? B

2.A.70.2.1 MSS H⁺ symport? B

2.A.70.1.1 MSS Na⁺ symport B

Oxalate 2.A.1.11.1 MFS solute:solute antiport B

Oxaloacetate 2.A.29.15.1 MC solute:solute antiport Y Mito

Tricarboxylates 2.A.29.7.1 MC solute:solute antiport Mito

2.A.54.1.1 MTC H⁺ symport Mito

2.A.80 Tct H⁺ symport? B

II.D. Organic anions (excluding carboxylates)

Glucose phosphate 2.A.1.4.1 MFS P_i antiport B

Glucose 6-phosphate 2.A.1.4.5 MFS P_i antiport An

2.A.50.2.1 TP-NST P_i antiport Pl plastids

Glucose 6-phosphate (sensor) 2.A.1.4.4 MFS ? B

Phosphoglycerates 2.A.1.4.2 MFS P_i antiport B

Glycerol phosphate 2.A.1.4.3 MFS P_i antiport B

Hexose phosphates 2.A.1.4.1 MFS P_i antiport B

Phosphoenolpyruvate 2.A.1.4.2 MFS P_i antiport B

2.A.50.3.1 TP-NST P_i antiport Pl Chloro

Sugar phosphates 2.A.1.4.1 MFS P_i antiport B

Triose phosphate 2.A.50.1.1 TP-NST P_i antiport Pl Chloro

2.A.50.2.1 TP-NST P_i antiport Pl plastids

III.A. Amino acids and conjugates

Acidic amino acids 2.A.3.10.13 APC H⁺ symport Y

Alanine 2.A.3.1.7 APC H⁺ symport Y

2.A.25.1.1 AGCS Na⁺ symport B

2.A.25.1.2 AGCS Na⁺ or H⁺ symport B

b-Alanine 2.A.3.1.5 APC H⁺ symport B

g-Aminobutyrate 2.A.3.1.4 APC H⁺ symport B

2.A.3.1.5 APC H⁺ symport B

2.A.3.7.1 APC glutamate antiport B

2.A.18.5.1 AAAP H⁺ symport? An

2.A.22.3.1-2 NSS Na⁺ symport An

Arginine 2.A.3.10.4 APC H⁺ symport Y

2.A.3.2.3 APC antiport with ornithine B

2.A.65.1.1 LysE H⁺ antiport? B

Aromatic amino acids 2.A.3.1.3 APC H⁺ symport B

Asparagine 2.A.3.1.8 APC H⁺ symport B

2.A.3.10.7, -13 APC H⁺ symport Y

Aspartate 2.A.13.1.1 Dcu solute:solute antiport B

2.A.23.1.1 DAACS H⁺ symport B

2.A.23.1.2 DAACS H⁺ or Na⁺ symport B, An

2.A.23.2.1 DAACS H⁺ or Na⁺ symport B, An

Basic amino acids 2.A.3.1.19 APC H⁺ symport Y

2.A.3.3.1, -2 APC H⁺ symport An

2.A.3.8.3 APC uniport or H⁺ symport An

2.A.29.9.1 MC solute:solute antiport Mito

Branched-chain amino acids 2.A.3.10.11 APC H⁺ symport Y

2.A.26.1.1-3 LIVCS H⁺ or Na⁺ symport B

Cystine 2.A.3.8.5 APC glutamate antiport An

2.A.43.1.1 LCT H⁺ antiport An

General amino acids 2.A.3.3.3 APC H⁺ symport Pl

2.A.3.10.2, -14 APC H⁺ symport Y

2.A.18.2.1 AAAP H⁺ symport Pl

Glutamate 2.A.3.7.1 APC g-aminobutyrate antiport B

2.A.3.8.5 APC cystine antiport An

2.A.3.10.13 APC H⁺ symport Y

2.A.23.1.1 DAACS H⁺ symport B

2.A.23.1.2 DAACS H⁺ or Na⁺ symport B, An

2.A.23.2.1 DAACS H⁺ or Na⁺ symport B, An

2.A.23.2.2 DAACS Na⁺ symport An

2.A.27.1.1 ESS Na⁺ symport B

2.A.3.7.1 APC H⁺ symport B

Glutamine 2.A.3.10.5, -7 APC H⁺ symport Y

Glycine 2.A.3.1.7 APC H⁺ symport B

2.A.22.2.2 NSS Na⁺ symport An

2.A.25.1.1 AGCS Na⁺ symport B

Histidine 2.A.3.1.5, -9 APC H⁺ symport Y, Fu

2.A.3.10.1 APC H⁺ symport Y

2.A.17.3.2-3 POT H⁺ symport Pl

Homoserine (efflux) 2.A.76.1.1 RhtB H⁺ antiport B

Homoserine lactone (efflux) 2.A.76.1.1 RhtB H⁺ antiport B

Isoleucine 2.A.3.10.6 APC H⁺ symport Y

2.A.26.1.1-3 LIVCS H⁺ or Na⁺ symport B

2.A.78 LIV-E H⁺ symport A, B, E

Leucine 2.A.3.10.6 APC H⁺ symport Y

2.A.26.1.1-3 LIVCS H⁺ or Na⁺ symport B

2.A.78 LIV-E H⁺ symport A, B, E

Leucine (sensor) 2.A.3.10.12 APC ? Y

Lysine 2.A.3.1.2 APC H⁺ symport B

2.A.3.2.2 APC solute:solute antiport B

2.A.3.2.4 APC ? B

2.A.3.10.10 APC H⁺ symport Y

Lysine (efflux) 2.A.75.1.1 LysE H⁺ antiport? B

Methionine 2.A.3.8.4 APC H⁺ symport Y

Neutral amino acids 2.A.3.8.1-3, -6 APC uniport or H⁺ symport An

2.A.18.4.1 AAAP H⁺ symport Fu

2.A.23.3.1 DAACS Na⁺ symport An

Neutral and acidic amino acids 2.A.23.3.2 DAACS Na⁺ symport An

Neutral and basic amino acids 2.A.23.3.3 DAACS Na⁺ symport An

Ornithine 2.A.3.2.1 APC antiport with putrescine B

2.A.3.2.3 APC antiport with arginine B

Phenylalanine 2.A.3.1.1 APC H⁺ symport B

Proline 2.A.1.6.4 MFS H⁺ symport B

2.A.3.1.6 APC H⁺ symport Y

2.A.3.10.3 APC H⁺ symport Y

2.A.15.1.2 BCCT H⁺ symport B

2.A.18.3.1 AAAP H⁺ symport Pl

2.A.21.2.1 SSS Na⁺ symport B

2.A.22.2.1 NSS Na⁺ symport An

Serine 2.A.3.1.7 APC H⁺ symport B

2.A.23.4.1 DAACS Na⁺ symport B

2.A.42.2.1 HAAAP H⁺ symport B

2.A.79 ThrE H⁺ antiport A, B, E

Threonine 2.A.3.1.9 APC H⁺ symport B

2.A.23.4.1 DAACS Na⁺ symport B

2.A.42.2.2 HAAAP H⁺ symport B

2.A.78 ThrE H⁺ antiport A, B, E

Threonine (efflux) 2.A.76.1.2 RhtB H⁺ antiport? B

Tryptophan 2.A.3.1.16-17 APC H⁺ symport Y

2.A.22.4.1 SSS Na⁺ symport B

2.A.42.1.2-3 HAAAP H⁺ symport B

Tyrosine 2.A.3.10.8-9 APC H⁺ symport Y

2.A.42.1.1 HAAAP H⁺ symport B

2.A.45.2.1 ArsB ? An

Valine 2.A.3.10.6, -9 APC H⁺ symport Y

2.A.26.1.1-3 LIVCS H⁺ or Na⁺ symport B

III.B. Amines, amides, and polyamines

Acetylcholine 2.A.1.2.13 MFS H⁺ antiport An

Acylcarnitine 2.A.1.19.3 MFS uniport; Na⁺ symport An

2.A.29.8.1 MC solute:solute antiport Mito

S-Adenosylmethionine 2.A.3.10.15 APC H⁺ symport Y

Amines, organic (nonspecific) 2.A.1.19.1-5 MFS uniport? An

g-Aminobutyrate 2.A.3.4.2 APC H⁺ symport Fu, Y

2.A.3.7.1 APC H⁺ symport B

Auxin 2.A.18.1.1 AAAP H⁺ symport Pl

2.A.69.1.1-2 AEC uniport; H⁺ antiport? Pl

Betaine 2.A.1.6.4 MFS H⁺/Na⁺ symport B

2.A.23.3.1 SSS Na⁺ symport An

Butyrobetaine 2.A.1.19.3 MFS uniport; Na⁺ symport An

Cadaverine 2.A.3.2.2 APC antiport with lysine B

Carnitine 2.A.1.19.3 MFS uniport; Na⁺ symport An

2.A.15.2.1 BCCT H⁺ symport B

2.A.29.8.1 MC solute:solute antiport Mito

Choline 2.A.3.4.1 APC H⁺ symport? Y

2.A.15.3.1 BCCT H⁺ symport B

2.A.22.3.5 NSS Na⁺ symport An

Creatine 2.A.22.3.4 NSS Na⁺ symport An

Dopamine 2.A.1.22.1 MFS ? An

2.A.22.1.3 NSS Na⁺ symport An

Ectosine 2.A.15.1.2 BCCT H⁺ symport B

Ethanolamine 2.A.3.5.1 APC H⁺ symport B

Glycine betaine 2.A.1.6.4 MFS H⁺,Na⁺ symport B

2.A.1.19.3 MFS uniport; Na⁺ symport An

2.A.15.1.1-2 BCCT H⁺ symport B

2.A.22.3.1 NSS Na⁺ symport An

Guanidinium 2.A.1.19.2 MFS H⁺ antiport An

Monoamines 2.A.1.2.11 MFS H⁺ antiport An

2.A.1.2.12 MFS H⁺ antiport An

Neurotransmitters (cationic) 2.A.1.19.1 MFS uniport? An

2.A.1.19.5-7 MFS uniport? An

2.A.1.22.1 MFS uniport or H⁺ or Na⁺ symport An

Noradrenaline 2.A.22.1.2 NSS Na⁺ symport An

Organic cations 2.A.1.19.1-5 MFS uniport or H⁺ or Na⁺ symport An

Polyamines (efflux) 2.A.1.2.16 MFS H⁺ antiport An

Putrescine 2.A.3.2.1 APC H⁺ symport;
antiport with ornithine B

Quaternary amines 2.A.77.1.2 CadD H⁺ antiport? B

Serotonin 2.A.22.1.1 NSS Na⁺ symport An

Taurine 2.A.22.3.3 NSS Na⁺ symport An

Tetramethyl ammonium 2.A.1.19.1 MFS H⁺ antiport; uniport? An

Urea 2.A.21.6.1 SSS ? Y

III.C. Peptides

Glycopeptides, cell-wall derived 2.A.1.25.2 MFS H⁺ symport? B

Peptides 2.A.17.1-4 POT H⁺ symport B, E

2.A.67.1-2 OPT H⁺ symport? B, A, Y, Pl

9.A.18 PUP ? B

Peptides, antibacterial (efflux) 2.A.6.2.5 RND H⁺ antiport B

Peptides, cell-wall derived 2.A.1.25.2 MFS H⁺ symport? B

IV.A. Nucleobases

Allantoin 2.A.39.3.1 NCS1 H⁺ symport Y

Cytosine 2.A.39.1.1 NCS1 H⁺ symport B

2.A.39.2.1 NCS1 H⁺ symport Y

Nucleobases 2.A.74.1.1 MET H⁺ antiport? An

Purines 2.A.39.2.1 NCS1 H⁺ symport Y

2.A.40.2.1 NCS2 H⁺ symport B

2.A.40.5.1 NCS2 H⁺ symport Fu

Uracil 2.A.39.3.2 NCS1 H⁺ symport Y

2.A.40.1.1 NCS2 H⁺ symport B

Uric acid 2.A.40.4.1 NCS2 H⁺ symport Fu

Xanthine 2.A.40.3.1 NCS2 H⁺ symport B

2.A.40.4.1 NCS2 H⁺ symport Fu

IV.B. Nucleosides

Nucleosides 2.A.1.10.1 MFS H⁺ symport B

2.A.21.3.3 SSS Na⁺ symport An

2.A.41.1.1 CNT H⁺ symport B

2.A.41.2.2-5 CNT Na⁺ symport An

2.A.57.1-3 ENT uniport Y, Pr, An

2.A.74.1.1 MET H⁺ antiport? An

9.A.6.1.1 INT ? An

Nucleosides
(pyrimidine-specific) 2.A.41.1.2 CNT Na⁺ symport B

Nucleosides (purine-specific) 2.A.41.2.1 CNT Na⁺ symport An

Uridine 2.A.39.3.2-3 NCS1 H⁺ symport Y

Xanthosine 2.A.1.10.2 MFS H⁺ symport B

IV.C. Nucleotides

ADP 2.A.12.1.1-2 AAA solute:solute antiport B

2.A.12.2.1 AAA solute:solute antiport Pl

2.A.29.1.1 MC solute:solute antiport Mito

ATP 2.A.12.1.1 AAA solute:solute antiport B

2.A.12.1.2 AAA solute:solute antiport Pl

2.A.29.1.1 MC solute:solute antiport Mito

Nucleoside triphosphates 2.A.12.3.1 AAA H⁺ symport B

V.A. Vitamins/cofactor precursors

L-Ascorbate 2.A.40.6.1 NCS2 Na⁺ symport An

p-Aminobenzoylglutamate 2.A.68.1.1 AbgT H⁺ symport B

Anionic vitamins 2.A.21.5.2 SSS Na⁺ symport An

Biopterin 2.A.71.1.1-4 FBT H⁺ symport? Pr

Biotin 2.A.21.5.2 SSS Na⁺ symport An

Cationic vitamins 2.A.1.19.1 MFS uniport An

Flavin adenine dinucleotide 2.A.29.10.1 MC ? Mito

Folate (reduced) 2.A.48.1.1 RFC H⁺ symport An

Folate 2.A.71.1.1-4 FBT H⁺ symport? Pr

5-Formyltetrahydrofolate 2.A.48.1.1 RFC Na⁺ symport? An

Lipoate 2.A.21.5.2 SSS Na⁺ symport An

Nicotinate 2.A.65.1.1 BRT H⁺ symport An

Panthothenate 2.A.21.1.1 SSS Na⁺ symport B

Panthothenate 2.A.21.5.2 SSS Na⁺ symport An

Tetrahydrofolate 2.A.48.1.1 RFC Na⁺ symport? An

Thiamine 2.A.39.4.1 NCS1 H⁺ symport Y

2.A.48.2.1 RFC Na⁺ symport? An

V.B. Enzyme and redox cofactors

Acetyl coenzyme A 2.A.1.25.1 MFS solute:solute antiport An (ER)

S-Adenosylmethionine 2.A.3.10.15 APC H⁺ symport Y

CMP-sialate 2.A.50.7.1 TP-NST CMP antiport An (ER)

Coenzyme A 2.A.1.25.1 MFS solute:solute antiport An (ER)

Flavin adenine dinucleotide 2.A.29.10.1 MC ? Mito

GDP-mannose 2.A.50.8.1 TP-NST GMP antiport An, Y (ER)

Nicotinamide mononucleotide 9.A.4.1.1 PnuC ? B

UDP-N-acetylglucosamine 2.A.50.5.1 TP-NST UMP antiport Y, An (ER)

UDP-galactose 2.A.50.6.1 TP-NST UMP antiport An (ER)

V.C. Siderophores and Fe-siderophore complexes

Fe-enterobactin 2.A.1.16.2 MFS H⁺ symport? Y

Fe-ferrioxamine 2.A.1.16.1 MFS H⁺ symport? Y

Fe-siderophore 2.A.1.16.1 MFS H⁺ symport? Y

Fe-triacetylfusarinine 2.A.1.16.3 MFS H⁺ symport? Y

V.D. Signaling molecules

Acyl L-homoserine lactone 2.A.6.2.6 BRND H⁺ antiport B

Isoflavonoids 2.A.6.2.3 RND H⁺ antiport B

Nodulation factor 2.A.6.3.1 RND H⁺ antiport B

Prostaglandins 2.A.60.1.2 OAT ? An

Steroid hormones 2.A.1.19.4 MFS ? An

2.A.6.6 RND ? An, Y

Thyroid hormones (thyroxine,
triiodothyronine) 2.A.60.1.3, -7 OAT ? An

VI.A. Multiple drugs and dyes

Multiple drugs 2.A.1.2.5 MFS H⁺ antiport B

2.A.1.2.6 MFS H⁺ antiport Y

2.A.1.2.7 MFS H⁺ antiport B

2.A.1.2.8 MFS H⁺ antiport B

2.A.1.2.9 MFS H⁺ antiport B

2.A.1.2.10 MFS H⁺ antiport B

2.A.1.2.11-12 MFS H⁺ antiport An

2.A.1.2.16-17 MFS H⁺ antiport An

2.A.1.3.1 MFS H⁺ antiport Y

2.A.1.3.2 MFS H⁺ antiport B

2.A.1.3.3 MFS H⁺ antiport B

2.A.1.3.4 MFS H⁺ antiport B

2.A.1.3.5 MFS H⁺ antiport B

2.A.1.21.1-4 MFS H⁺ antiport B

2.A.6.2.1-2, -6 RND H⁺ antiport B

Multiple drugs (cationic) 2.A.1.19.1 MFS uniport An

Multiple drugs
(aminoglycosides) 2.A.1.20.1 MFS H⁺ antiport? B

Multiple drugs and dyes
(cationic) 2.A.7.1.1-2 SMR H⁺ antiport B

Multiple drugs (antibiotics)
(uptake) 2.A.17.4.1 POT H⁺ symport An

Multiple drugs (antibiotics)
(uptake) 2.A.1.25.2 MFS H⁺ symport B

Multiple drugs (antibiotics) 2.A.66.1-3 MATE H⁺ antiport B, Y

2.A.74.1.1-2 MET H⁺ antiport? An

Xenobiotics 2.A.1.19.1 MFS uniport An

VI.B. Specific drugs

Acriflavin 2.A.1.2.8 MFS H⁺ antiport B

2.A.1.3.3 MFS H⁺ antiport B

Actinorhodin 2.A.1.3.7 MFS H⁺ antiport B

2.A.6.5.1 RND H⁺ antiport B

Amiloride 2.A.1.2.1 MFS H⁺ antiport Y

Aminoglycosides 2.A.1.20.1 MFS H⁺ antiport? B

Aminotriazole 2.A.1.3.1 MFS H⁺ antiport Y

Ampicillin (in) 2.A.1.25.2 MFS H⁺ symport? B

Benomyl 2.A.1.2.6 MFS H⁺ antiport Y

Bicyclomycin 2.A.1.2.7 MFS H⁺ antiport B

Bile acids 2.A.1.3.13 MFS H⁺ antiport B

Bleomycin 2.A.1.21.2 MFS H⁺ antiport B

Carbonylcyanide
m-chlorophenylhydrazone
(CCCP) 2.A.1.2.9

MFS H⁺ antiport B

2.A.1.3.2 MFS H⁺ antiport B

Cephamycin 2.A.1.3.8 MFS H⁺ antiport B

Chloramphenicol 2.A.1.2.3 MFS H⁺ antiport B

2.A.1.2.8 MFS H⁺ antiport B

Cycloheximide 2.A.1.2.2 MFS H⁺ antiport Y

2.A.1.2.6 MFS H⁺ antiport Y

Daunomycin 2.A.1.2.5 MFS H⁺ antiport B

Daunorubicin 2.A.1.2.11 MFS H⁺ antiport An

Erythromycin 2.A.1.21.1 MFS H⁺ antiport B

Ethidium bromide 2.A.1.2.5 MFS H⁺ antiport B

2.A.1.2.8 MFS H⁺ antiport B

2.A.1.2.11 MFS H⁺ antiport An

2.A.1.3.3 MFS H⁺ antiport B

2.A.66.1.1 MATE H⁺ antiport B

Ethionine 2.A.66.3.1 MATE H⁺ antiport Y

Fluconazole 2.A.1.2.17 MFS H⁺ antiport Y

Fluoroquinolones 2.A.1.2.8 MFS H⁺ antiport B

2.A.1.3.3 MFS H⁺ antiport B

Hydrophobic uncouplers 2.A.1.2.9 MFS H⁺ antiport B

Isoflavonoid 2.A.6.2.3 RND H⁺ antiport B

Kanamycin 2.A.1.20.1 MFS H⁺ antiport? B

2.A.66.1.1 MATE H⁺ antiport B

b-Lactams (uptake) 2.A.17.4.1 POT H⁺ symport An

Lincomycin 2.A.1.3.9 MFS H⁺ antiport B

Macrolides 2.A.1.21.1 MFS H⁺ antiport B

Methotrexate 2.A.1.2.6 MFS H⁺ antiport Y

2.A.48.1.1 RFC Na⁺ symport? An

2.A.60.1.4 OAT ? An

Methylenomycin 2.A.1.3.10 MFS H⁺ antiport B

Methylviologen 2.A.1.3.14 MFS H⁺ antiport B

Nalidixic acid 2.A.1.3.2 MFS H⁺ antiport B

4-Nitroquinoline N-oxide 2.A.1.3.1 MFS H⁺ antiport Y

Norfloxacin 2.A.66.1.1 MATE H⁺ antiport B

Oleandomycin 2.A.1.21.1 MFS H⁺ antiport B

Organocations 2.A.1.3.4 MFS H⁺ antiport B

Organomercurials 2.A.1.3.2 MFS H⁺ antiport B

Paraquat 2.A.1.2.16 MFS H⁺ antiport Y

Penicillin and derivatives (in) 2.A.1.25.2 MFS H⁺ symport B

Pristinamycin 2.A.1.3.5 MFS H⁺ antiport B

Puromycin 2.A.1.3.11 MFS H⁺ antiport B

2.A.1.21.2 MFS H⁺ antiport B

Quinoline 2.A.1.2.10 MFS H⁺ antiport B

Rifamycin 2.A.1.3.5 MFS H⁺ antiport B

2.A.1.3.15 MFS H⁺ antiport B

Streptomycin 2.A.1.20.1 MFS H⁺ antiport? B

2.A.66.1.1 MATE H⁺ antiport B

Sulfathiazole 2.A.1.27 MFS H⁺ antiport B

Tetracenomycin 2.A.1.3.12 MFS H⁺ antiport B

Tetracycline 2.A.1.2.4 MFS H⁺ antiport B

2.A.1.3.6 MFS H⁺ antiport B

2.A.1.21.2-3 MFS H⁺ antiport B

VI.C. Bile salts and conjugates

Bile salts 2.A.1.19.4 MFS uniport or H⁺ symport An

2.A.6.2.5 RND H⁺ antiport B

2.A.28.1.1 BASS Na⁺ symport An

Bile salt conjugates 2.A.1.23.1 MFS H⁺ symport B

VI.D. Sterols/steroids

Steroids 2.A.6.2.5 RND H⁺ antiport B

Sterols (nonspecific) 2.A.1.19.4 MFS uniport; H⁺ symport An

2.A.74.1.1 MET H⁺ antiport? An

Sterols (probably nonspecific) 2.A.6.6.1, -3 RND H⁺ antiport? Y, An

Aldosterone 2.A.6.6.1, -3 RND H⁺ antiport? Y, An

Cardiac glycosides 2.A.6.6.1, -3 RND H⁺ antiport? Y, An

Cortisol 2.A.6.6.1, -3 RND H⁺ antiport? Y, An

Dexamethasone 2.A.6.6.1, -3 RND H⁺ antiport? Y, An

Estrone 3-sulfate 2.A.6.6.1, -3 RND H⁺ antiport? Y, An

Estradiol 17-glucuronide 2.A.6.6.1, -3 RND H⁺ antiport? Y, An

Ouabain 2.A.6.6.1, -3 RND H⁺ antiport? Y, An

Steroid conjugates 2.A.6.6.1, -3 RND H⁺ antiport? Y, An

Steroid hormones (conjugates
and nonconjugates) 2.A.60.1 OAT ? An

VII.A. Carbohydrates

Lipooligosaccharides 2.A.6.3.1 RND H⁺ antiport? B

Exo- and capsular
polysaccharides (out) 9.A.1.2.1-2 PST H⁺ antiport? B

Lipopolysaccharide (out) 9.A.1.1 PST H⁺ antiport? B

VII.B. Proteins

Proteins (nonspecific) 2.A.6.4.1 RND, SecDF H⁺ antiport? B, A

2.A.9 Oxa1 ? B, E

Redox enzymes/proteins 2.A.64.1.1 TAT PMF-driven B, A, E

VII.D. Lipids

Lipids 2.A.6.5.2 RND PMF-driven B

2.A.31.1.1 AE ? An

^a Abbreviations used for types of organisms, organelles and viruses are as follows: B, Bacteria; A, Archaea; E, Eucarya; G^-, Gram-negative bacteria; G⁺, Gram-positive bacteria; Y, yeasts; Fu, fungi; Pr, protozoans; Pl, plants; An, animals; Mito, mitochondria; Chloro, chloroplasts; ER, endoplasmic reticulum; Bp, bacteriophage; V, virus

^b D-erythro-3-Deoxyhexulosonate was formerly called 2-keto-3-deoxygluconate hence the family name KDGT; it may also be described as 2-dehydro-3-deoxy-D-gluconate.

Continued with Class 4
Return to Membrane Transport Proteins home page
Return to Biochemical Nomenclature home page

Substrate	TC number	Family	Energy source or mechanism	Distribution^a
Ag⁺ (efflux)	2.A.6.1.3	RND	Ag⁺:H⁺ antiport	B
H⁺	2.A.33.1.1	NhaA	H⁺:Na⁺ antiport	B
	2.A.34.1.1	NhaB	H⁺:Na⁺ antiport	B
	2.A.35.1.1	NhaC	H⁺:Na⁺ antiport	B
	2.A.36.1.3-5	CPA1	H⁺:Na⁺ antiport	B, E
	2.A.37.1-5	CPA2	H⁺:Na⁺ antiport	B, Y
	2.A.38.1-4	Trk	H⁺,K⁺ symport	B, Pl
	2.A.62.1.1	NhaD	H⁺:Na⁺ antiport	B
	2.A.63.1.1-3	CPA3	H⁺:Na⁺ or K⁺ antiport	B
H⁺ or OH^-	2.A.29.3.1	MC	uniport (?)	Mito
K⁺	2.A.19.3.2	CaCA	K⁺,Ca²⁺ symport; Na⁺ or H⁺ antiport	An
	2.A.30.1-3, -7	CCC	Na⁺, Cl^- and K⁺, Cl^- symport	An, Pl
	2.A.30.5-6	CCC	K⁺, Cl^- symport	An
	2.A.36.4.1	CPA1	K⁺:H⁺ antiport	Y
	2.A.37.1-5	CPA2	K⁺:H⁺ antiport	B, Y
	2.A.38.1-4	Trk	cation uptake (PMF?); K⁺, H⁺ or Na⁺ symport	B, Pl
	2.A.63.1.1	CPA3	K⁺:H⁺ antiport	B
	2.A.72.1-3	KUP	K⁺ uptake (K⁺,H⁺ or K⁺,Na⁺ symport)	B, Y, Pl
	2.A.30.1-3	CCC	Na⁺, K⁺, 2Cl^- symport	An
Na⁺	2.A.30.4.1	CCC	Na⁺, Cl^- symport	An
	2.A.30.7.1	CCC	Na,K,Cl₂ symport	Pl
	2.A.33.1.1	NhaA	Na⁺:H⁺ antiport	B
	2.A.34.1.1	NhaB	Na⁺:H⁺ antiport	B
	2.A.35.1.1	NhaC	Na⁺:H⁺ antiport	B
	2.A.36.1-4	CPA1	Na⁺:H⁺ antiport	B, E
	2.A.37.2.1	CPA2	Na⁺:H⁺ antiport	B
	2.A.38.3.1	Trk	Na⁺,H⁺ symport	Pl
	2.A.62.1.1	NhaD	Na⁺:H⁺ antiport	B
	2.A.63.1.2-3	CPA3	Na⁺:H⁺ antiport	B
NH₃ or NH₄⁺	2.A.49	Amt	uniport?	B, A, E

Al³⁺	9.A.17.2.1	MIT	uniport?	Y
Ca²⁺	2.A.19.1-4	CaCA	H⁺ or Na⁺ antiport	B, Y, Pl vacuoles, An
Cations, divalent; nonspecific	9.A.17.1-2	MIT	uniport?	B, Y
	2.A.3.10.1	APC	?	Y, Fu
	2.A.5.1.2	ZIP	PMF (uptake)	Pl
	2.A.55.1-2	Nramp	H⁺ symport	Y, An
Cd²⁺	2.A.4.1.1	CDF	PMF? (efflux)	B
	2.A.4.2.2	CDF	PMF? (uptake)	Mito
	2.A.6.1.2	HME	PMF (H⁺ antiport)	B
	2.A.77.1.1	CadD	PMF (efflux)	B
Co²⁺	2.A.4.1.1-2	CDF	PMF? (efflux)	B
	2.A.4.2.1	CDF	PMF? (uptake)	Mito
	2.A.6.1.1-2	RND	H⁺ antiport	B
	9.A.17.1.1	MIT	PMF? (uptake) (uniport?)	B
	2.A.52.1.2	NiCoT	PMF? (uptake)	B
Cu²⁺	9.A.11.1.1	Ctr1	PMF? (uptake)	Y
Cu²⁺	9.A.12.1.1	Ctr2	PMF? (uptake)	E
Fe²⁺	2.A.5.1.2	ZIP	PMF?	E
	9.A.17.1.1	MIT	PMF? (uptake)	B, A, Y
	9.A.9.1.1	FeT	PMF? (uptake)	Y
Fe³⁺	9.A.10.1.1	OfeT	PMF? (uptake)	B, Y
Hg²⁺	9.A.2.1.1	MerTP	PMF? (uptake)	B
Hg²⁺	9.A.3.1.1	MerC	PMF? (uptake)	B
Mg²⁺	2.A.11.1.1	CitMHS	H⁺ symport	B
	9.A.17.1.1	MIT	PMF? (uptake)	B
	9.A.19.1.1	MgtE	?	B, A
Mn²⁺	2.A.3.1.15	APC	PMF? (efflux)	Y
	2.A.5.2.1	ZIP	PMF (uptake)	Y
	2.A.19.2.2	CaCA	PMF (H⁺ antiport)	Y
	9.A.17.2.2	MIT	PMF? (efflux)	Y
	2.A.55.1.1-2	Nramp	H⁺ symport (uptake)	B, A, E
Ni²⁺	2.A.1.21.5	MFS	PMF? (efflux)	B
	2.A.6.1.1	RND	H⁺ antiport	B
	9.A.17.1.1	MIT	PMF? (uptake)	B
	2.A.52.1.1	NiCoT	uniport? (uptake)	B
Zn²⁺	2.A.4.1.1-2	CDF	PMF? (efflux)	B
	2.A.4.2.1-2	CDF	PMF? (uptake)	Mito
	2.A.4.2.3	CDF	PMF? (efflux)	An
	2.A.4.3.1	CDF	PMF? (uptake)	An vesicles
	2.A.5.1.1	ZIP	PMF? (uptake)	E
	2.A.6.1.2	RND	H⁺ antiport	B

Antimonite	2.A.45.1.1	ArsB	PMF (efflux)	B
Arsenite	2.A.45.1.1	ArsB	PMF (efflux)	B
Arsenite	2.A.59.1.1	ACR3	PMF (efflux)	Y
Bicarbonate	2.A.31.1.1	AE	anion antiport	An, Y
	2.A.31.2.1	AE	Na⁺ symport	An
	2.A.73.1.1	ICT	H⁺ symporter?	B
Chlorate	2.A.17.3.1-3	POT	H⁺ symport	Pl
Chloride	2.A.30.1-3	CCC	Na⁺,K⁺ symport	An
	2.A.30.4.1	CCC	Na⁺ symport	An
	2.A.30.5-6	CCC	K⁺ symport	An
	2.A.30.7.1	CCC	Na⁺,K⁺ symport	Pl
	2.A.31.1.1	AE	anion antiport	An, Y
Chromate	2.A.51.1.1	CHR	PMF (efflux)	B
Cyanate	2.A.1.17.1	MFS	H⁺ symport	B
Inorganic anions (general)	2.A.31.1.1	AE	anion antiport	E
Inorganic univalent anions (nonselective)	2.A.21.5.1	SSS	Na⁺ symport	An
Iodide	2.A.21.5.1	SSS	Na⁺ symport	An
Nitrate	2.A.1.8.2-6	MFS	H⁺ symport	B
Nitrate	2.A.17.3.1, -3	POT	H⁺ symport	Pl
Nitrite	2.A.1.8.1	MFS	uniport; H⁺ symport?	B
Nitrite	2.A.44.3.1	FNT	H⁺ symport?	B
Phosphate	2.A.1.4.1-4	MFS	H⁺ symport?; anion:anion antiport	B
	2.A.1.9.1-3	MFS	H⁺ symport	Y, Fu, Pl
	2.A.1.14.6	MFS	Na⁺ symport	An
	2.A.20.1-3	Pit	H⁺ or Na⁺ symport	B, A, Fu
	2.A.29.4.1	MC	OH^- antiport	Mito
	2.A.47.2.1	DASS	H⁺ symport	Y
	2.A.58.1.1	PNaS	Na⁺ symport	B, An
Silicate	2.A.32.1.1	Sit	Na⁺ symport	diatoms
Sulfate	2.A.29.15.1	MC	solute:solute antiport	Y Mito
	2.A.47.1.2	DASS	Na⁺ symport	An
	2.A.53.1-4	SulP	H⁺ symport or HCO₃ antiport	B, E
	2.A.51.1.2	CHR	H⁺ symport?	B
Thiosulfate	2.A.29.15.1	MC	solute:solute antiport	Y Mito
Tellurite	2.A.16.1.1	TDT	PMF (efflux)	B

Arabinitol	2.A.1.18.1	MFS	H⁺ symport	B
Arabinose	2.A.1.1.2	MFS	H⁺ symport	B
Arabinose	2.A.1.2.14-15	MFS	H⁺ antiport	B
Fructose	2.A.1.1.13	MFS	H⁺ symport	An
Fructose	2.A.1.1.16	MFS	uniport	Pr
L-Fucose	2.A.1.7.1	MFS	H⁺ symport	B
Galactose	2.A.21.3.1-2	SSS	Na⁺ symport	B, An
	2.A.1.1.1	MFS	H⁺ symport	B
	2.A.1.1.2	MFS	H⁺ symport	B
	2.A.11.6	MFS	uniport	Y
	2.A.11.9	MFS	H⁺ symport	Y
	2.A.17.2	MFS	H⁺ symport	B
Glucose	2.A.1.1.4	MFS	uniport	Y
	2.A.1.1.6	MFS	uniport	Y
	2.A.1.1.12	MFS	uniport	An
	2.A.1.1.16	MFS	uniport	Pr
	2.A.1.1.17	MFS	?	Pr
	2.A.1.7.2	MFS	H⁺ symport	B
	2.A.1.7.3	MFS	H⁺ symport	B
	2.A.9.2.1	RhaT	H⁺ symport	B
	2.A.21.3.1	SSS	Na⁺ symport	An
	2.A.21.3.1-4	SSS	Na⁺ symport	B, An
Glucose (sensor)	2.A.1.1.18-19	MFS	?	Y
a-Glucosides	2.A.1.1.11	MFS	H⁺ symport	Y
Glucuronide	2.A.2.3.1	GPH	H⁺ symport	B
Hexoses	2.A.11.5	MFS	uniport	Y, An
	2.A.1.1.14	MFS	H⁺ symport	Pl
	2.A.1.1.16	MFS	uniport	Pr
Hexuronates	2.A.1.14.2	MFS	H⁺ symport	B
myo-Inositol	2.A.1.1.8	MFS	H⁺ symport	?
	2.A.1.1.20	MFS	H⁺ symport	Pr
	2.A.21.4.1	SSS	Na⁺ symport	An
Isoprimeverose	2.A.2.3.3	GPH	H⁺ symport	B
Isopropyl-b-thiogalactoside (efflux)	2.A.1.20.1, -4	MFS	H⁺ antiport	B
Isopropyl-b-thiogalactoside (efflux)	2.A.1.2.15, -18	MFS	H⁺ antiport	B
Lactose	2.A.1.1.9	MFS	H⁺ symport	Y
	2.A.1.5.1	MFS	H⁺ symport	B
	2.A.2.2.1	GPH	H⁺ symport	B
Lactose (efflux)	2.A.1.20.1-2 and 4	MFS	H⁺ antiport	B
Maltose	2.A.1.1.10	MFS	H⁺ symport	Y
Maltose (efflux)	2.A.1.20.1	MFS	H⁺ antiport	B
Mannose	2.A.1.1.16	MFS	uniport	Pr
Mannose	2.A.1.7.3	MFS	H⁺ symport	B
Melibiose	2.A.1.5.4	MFS	H⁺ symport	B
Melibiose	2.A.2.1.1	GPH	H⁺ or Na⁺ symport	B
Melibiose (efflux)	2.A.1.2.18	MFS	H⁺ antiport	B
Multiple sugars	2.A.1.20	MFS	H⁺ antiport	?
Pentosides	2.A.2.3.2-3	GPH	H⁺ symport	B
Raffinose	2.A.1.5.2	MFS	H⁺ symport	B
Raffinose	2.A.2.2.2	GPH	H⁺ symport	B
L-Rhamnose	2.A.9.1.1	RhaT	H⁺ symport	B
Ribitol	2.A.1.18.2	MFS	H⁺ symport	B
Ribose	2.A.9.3.1	RhaT	H⁺ symport	B
Sialic acid	2.A.1.12.1	MFS	H⁺ symport	B
Sucrose	2.A.1.5.3	MFS	H⁺ symport	B
Sucrose	2.A.2.4.1	GPH	H⁺ symport	Pl
Sugars (efflux), fairly nonspecific	2.A.1.20.1-2, -4	MFS	H⁺ antiport	B
Xylose	2.A.1.1.2	MFS	H⁺ symport	B
Xylose	2.A.1.1.3	MFS	H⁺ symport	B

Acetate	2.A.44.4.1	FNT	H⁺ symport	Y
Allantoate	2.A.1.14.4	MFS	H⁺ symport	Y
Auxin (indole 3-acetate)	2.A.18.1.1	AAAP	H⁺ symport	Pl
Auxin (out)	2.A.69.1.1	AEC	uniport? H⁺ antiport?	Pl
Benzoate	2.A.1.15.5	MFS	H⁺ symport	B
Benzoate	2.A.46.1.1	BenE	H⁺ symport	B
Bile salts	2.A.1.3.13	MFS	H⁺ symport	B
	2.A.6.2.5	RND	H⁺ antiport	B
	2.A.28.1.1	BASS	Na⁺ symport	An
Bile salts (conjugated)	2.A.1.23.1	MFS	H⁺ symport	B
Bile salts (conjugated and unconjugated)	2.A.60.1	OAT	?	An
Bilirubin	2.A.65.1.1	BRT	H⁺ symport?	An
Cyanate	2.A.1.17.1	MFS	H⁺ symport	B
D-erythro-3-Deoxyhexulosonate ^b	2.A.10.1.1	KDGT	H⁺ symport	B
2,4-Dichlorophenoxyacetate	2.A.1.15.3	MFS	H⁺ symport	B
Digoxin	2.A.60.1.1	OAT	uniport; anion antiport	An
Fatty acids	2.A.6.2.5	RND	H⁺ antiport	B
Formate	2.A.1.11.1	MFS	solute:solute antiport	B
	2.A.44.1.1	FNT		B
	2.A.44.2.1	FNT	uptake?	B
Galacturonate	2.A.1.14.2	MFS	H⁺ symport	B
Glucarate	2.A.1.14.1	MFS	H⁺ symport	B
Gluconate	2.A.8.1.1	GntP	H⁺ symport	B
Gluconate	2.A.8.1.2	GntP	H⁺ symport	B
Glucuronate	2.A.1.14.2	MFS	H⁺ symport	B
Hexuronate	2.A.1.14.2	MFS	H⁺ symport	B


4-Hydroxybenzoate	2.A.1.15.1	MFS	H⁺ symport	B
3-Hydroxyphenyl acetate	2.A.1.14.9	MFS	H⁺ symport	B
3-Hydroxyphenyl propionate	2.A.1.15.2	MFS	H⁺ symport	B
L-Idonate	2.A.8.1.2	GntP	H⁺ symport	B
Lactate	2.A.1.12.2	MFS	H⁺ symport	Y
	2.A.1.13.1	MFS	H⁺ symport	Y, Fu, An
	2.A.14.1.1	LctP	H⁺ symport	B
	2.A.24.3.2	CCS	solute:solute antiport	B
Leucotrienes	2.A.60.1.7	OAT	?	An
4-Methylphthalate	2.A.1.6.5	MFS	H⁺ symport	B
Mevalonate	2.A.1.13.1	MFS	H⁺ symport	Y, Fu, An
Monocarboxylates	2.A.1.13.1	MFS	H⁺ symport	Y, Fu, An
cis,cis-Muconate	2.A.1.15.4	MFS	H⁺ symport	B
Organic anions (nonselective)	2.A.1.19.4, -7-8	MFS	H⁺ symport?	An
	2.A.21.5.2	SSS	Na⁺ symport	An
	2.A.60.1	OAT	uniport; anion antiport	An
	2.A.65.1.1	BRT	H⁺ symport?	An
Phenylpropionate	2.A.1.27.1	MFS	H⁺ symport	B
Phenylacetate	2.A.21.7.1	SSS	H⁺ symport	B
Phthalate	2.A.1.14.5	MFS	H⁺ symport	B
Prostaglandins	2.A.60.1.2, -7	OAT	uniport; anion antiport	An
Protocatechuate	2.A.1.15.1	MFS	H⁺ symport	B
Pyruvate	2.A.1.12.1	MFS	H⁺ symport	Y
Pyruvate	2.A.1.13.1	MFS	H⁺ symport	Y, Fu, An
Quinate	2.A.1.1.7	MFS	H⁺ symport	Fu
Shikimate	2.A.1.6.6	MFS	H⁺ symport	B
Sialate	2.A.1.12.1	MFS	H⁺ symport	B
Tartrate	2.A.1.14.3	MFS	H⁺ symport	B
Tartrate	2.A.47.3.3	DASS	solute:solute antiport	B
Taurocholate	2.A.60.1.3, -7	OAT	?	An
Thromboxanes	2.A.60.1.2, -7	OAT	?	An
Thyroid hormones (thyroxin; triiodothyronine)	2.A.60.1.3, -7	OAT	?	An

Citrate	2.A.1.6.1	MFS	H⁺ symport	B
	2.A.11.1.1	CitMHS	Mg²⁺,H⁺ symport	B
	2.A.11.1.2	CitMHS	H⁺ symport	B
	2.A.24.1.1; -3.1, -3.2	CCS	Na⁺ symport	B
	2.A.47.1.3, -3.2	DASS	Na⁺ symport; solute:solute antiport	B, An
Dicarboxylates	2.A.1.6.3	MFS	H⁺ symport	B
	2.A.13.1.1-2	Dcu	solute:solute antiport	B
	2.A.16.2.1	TDT	H⁺ symport	Y
	2.A.23.1.3	DAACS	H⁺ symport	B
	2.A.29.2.1-2; -13.1	MC	solute:solute antiport	Mito
	2.A.47.1.1, -3	DASS	Na⁺ symport	An
	2.A.47.3.1, -3	DASS	solute:solute antiport	B, Chloro
	2.A.56.1.1	TRAP-T	H⁺ symport	B
	2.A.61.1.1	DcuC	H⁺ symport	B
a-Ketoglutarate	2.A.1.6.2	MFS	H⁺ symport	B
Malate	2.A.16.2.1	TDT	H⁺ symport?	Y
	2.A.24.2.1	CCS	H⁺ symport	B
	2.A.69.3.1	AEC	H⁺ symport?	B
Malonate	2.A.29.15.1	MC	solute:solute antiport	Y Mito
	2.A.69.2.1	AEC	H⁺ symport?	B
	2.A.70.2.1	MSS	H⁺ symport?	B
	2.A.70.1.1	MSS	Na⁺ symport	B
Oxalate	2.A.1.11.1	MFS	solute:solute antiport	B
Oxaloacetate	2.A.29.15.1	MC	solute:solute antiport	Y Mito
Tricarboxylates	2.A.29.7.1	MC	solute:solute antiport	Mito
	2.A.54.1.1	MTC	H⁺ symport	Mito
	2.A.80	Tct	H⁺ symport?	B

Glucose phosphate	2.A.1.4.1	MFS	P_i antiport	B
Glucose 6-phosphate	2.A.1.4.5	MFS	P_i antiport	An
Glucose 6-phosphate	2.A.50.2.1	TP-NST	P_i antiport	Pl plastids
Glucose 6-phosphate (sensor)	2.A.1.4.4	MFS	?	B
Phosphoglycerates	2.A.1.4.2	MFS	P_i antiport	B
Glycerol phosphate	2.A.1.4.3	MFS	P_i antiport	B
Hexose phosphates	2.A.1.4.1	MFS	P_i antiport	B
Phosphoenolpyruvate	2.A.1.4.2	MFS	P_i antiport	B
Phosphoenolpyruvate	2.A.50.3.1	TP-NST	P_i antiport	Pl Chloro
Sugar phosphates	2.A.1.4.1	MFS	P_i antiport	B
Triose phosphate	2.A.50.1.1	TP-NST	P_i antiport	Pl Chloro
Triose phosphate	2.A.50.2.1	TP-NST	P_i antiport	Pl plastids

Acidic amino acids	2.A.3.10.13	APC	H⁺ symport	Y
Alanine	2.A.3.1.7	APC	H⁺ symport	Y
	2.A.25.1.1	AGCS	Na⁺ symport	B
	2.A.25.1.2	AGCS	Na⁺ or H⁺ symport	B
b-Alanine	2.A.3.1.5	APC	H⁺ symport	B
g-Aminobutyrate	2.A.3.1.4	APC	H⁺ symport	B
	2.A.3.1.5	APC	H⁺ symport	B
	2.A.3.7.1	APC	glutamate antiport	B
	2.A.18.5.1	AAAP	H⁺ symport?	An
	2.A.22.3.1-2	NSS	Na⁺ symport	An
Arginine	2.A.3.10.4	APC	H⁺ symport	Y
	2.A.3.2.3	APC	antiport with ornithine	B
	2.A.65.1.1	LysE	H⁺ antiport?	B
Aromatic amino acids	2.A.3.1.3	APC	H⁺ symport	B
Asparagine	2.A.3.1.8	APC	H⁺ symport	B
Asparagine	2.A.3.10.7, -13	APC	H⁺ symport	Y
Aspartate	2.A.13.1.1	Dcu	solute:solute antiport	B
	2.A.23.1.1	DAACS	H⁺ symport	B
	2.A.23.1.2	DAACS	H⁺ or Na⁺ symport	B, An
	2.A.23.2.1	DAACS	H⁺ or Na⁺ symport	B, An
Basic amino acids	2.A.3.1.19	APC	H⁺ symport	Y
	2.A.3.3.1, -2	APC	H⁺ symport	An
	2.A.3.8.3	APC	uniport or H⁺ symport	An
	2.A.29.9.1	MC	solute:solute antiport	Mito
Branched-chain amino acids	2.A.3.10.11	APC	H⁺ symport	Y
Branched-chain amino acids	2.A.26.1.1-3	LIVCS	H⁺ or Na⁺ symport	B
Cystine	2.A.3.8.5	APC	glutamate antiport	An
Cystine	2.A.43.1.1	LCT	H⁺ antiport	An
General amino acids	2.A.3.3.3	APC	H⁺ symport	Pl
	2.A.3.10.2, -14	APC	H⁺ symport	Y
	2.A.18.2.1	AAAP	H⁺ symport	Pl
Glutamate	2.A.3.7.1	APC	g-aminobutyrate antiport	B
	2.A.3.8.5	APC	cystine antiport	An
	2.A.3.10.13	APC	H⁺ symport	Y
	2.A.23.1.1	DAACS	H⁺ symport	B
	2.A.23.1.2	DAACS	H⁺ or Na⁺ symport	B, An
	2.A.23.2.1	DAACS	H⁺ or Na⁺ symport	B, An
	2.A.23.2.2	DAACS	Na⁺ symport	An
	2.A.27.1.1	ESS	Na⁺ symport	B
	2.A.3.7.1	APC	H⁺ symport	B
Glutamine	2.A.3.10.5, -7	APC	H⁺ symport	Y
Glycine	2.A.3.1.7	APC	H⁺ symport	B
	2.A.22.2.2	NSS	Na⁺ symport	An
	2.A.25.1.1	AGCS	Na⁺ symport	B
Histidine	2.A.3.1.5, -9	APC	H⁺ symport	Y, Fu
	2.A.3.10.1	APC	H⁺ symport	Y
	2.A.17.3.2-3	POT	H⁺ symport	Pl
Homoserine (efflux)	2.A.76.1.1	RhtB	H⁺ antiport	B
Homoserine lactone (efflux)	2.A.76.1.1	RhtB	H⁺ antiport	B
Isoleucine	2.A.3.10.6	APC	H⁺ symport	Y
	2.A.26.1.1-3	LIVCS	H⁺ or Na⁺ symport	B
	2.A.78	LIV-E	H⁺ symport	A, B, E
Leucine	2.A.3.10.6	APC	H⁺ symport	Y
	2.A.26.1.1-3	LIVCS	H⁺ or Na⁺ symport	B
	2.A.78	LIV-E	H⁺ symport	A, B, E
Leucine (sensor)	2.A.3.10.12	APC	?	Y
Lysine	2.A.3.1.2	APC	H⁺ symport	B
	2.A.3.2.2	APC	solute:solute antiport	B
	2.A.3.2.4	APC	?	B
	2.A.3.10.10	APC	H⁺ symport	Y
Lysine (efflux)	2.A.75.1.1	LysE	H⁺ antiport?	B
Methionine	2.A.3.8.4	APC	H⁺ symport	Y
Neutral amino acids	2.A.3.8.1-3, -6	APC	uniport or H⁺ symport	An
	2.A.18.4.1	AAAP	H⁺ symport	Fu
	2.A.23.3.1	DAACS	Na⁺ symport	An
Neutral and acidic amino acids	2.A.23.3.2	DAACS	Na⁺ symport	An
Neutral and basic amino acids	2.A.23.3.3	DAACS	Na⁺ symport	An
Ornithine	2.A.3.2.1	APC	antiport with putrescine	B
Ornithine	2.A.3.2.3	APC	antiport with arginine	B
Phenylalanine	2.A.3.1.1	APC	H⁺ symport	B
Proline	2.A.1.6.4	MFS	H⁺ symport	B
	2.A.3.1.6	APC	H⁺ symport	Y
	2.A.3.10.3	APC	H⁺ symport	Y
	2.A.15.1.2	BCCT	H⁺ symport	B
	2.A.18.3.1	AAAP	H⁺ symport	Pl
	2.A.21.2.1	SSS	Na⁺ symport	B
	2.A.22.2.1	NSS	Na⁺ symport	An
Serine	2.A.3.1.7	APC	H⁺ symport	B
	2.A.23.4.1	DAACS	Na⁺ symport	B
	2.A.42.2.1	HAAAP	H⁺ symport	B
	2.A.79	ThrE	H⁺ antiport	A, B, E
Threonine	2.A.3.1.9	APC	H⁺ symport	B
	2.A.23.4.1	DAACS	Na⁺ symport	B
	2.A.42.2.2	HAAAP	H⁺ symport	B
	2.A.78	ThrE	H⁺ antiport	A, B, E
Threonine (efflux)	2.A.76.1.2	RhtB	H⁺ antiport?	B
Tryptophan	2.A.3.1.16-17	APC	H⁺ symport	Y
	2.A.22.4.1	SSS	Na⁺ symport	B
	2.A.42.1.2-3	HAAAP	H⁺ symport	B
Tyrosine	2.A.3.10.8-9	APC	H⁺ symport	Y
	2.A.42.1.1	HAAAP	H⁺ symport	B
	2.A.45.2.1	ArsB	?	An
Valine	2.A.3.10.6, -9	APC	H⁺ symport	Y
Valine	2.A.26.1.1-3	LIVCS	H⁺ or Na⁺ symport	B

Acetylcholine	2.A.1.2.13	MFS	H⁺ antiport	An
Acylcarnitine	2.A.1.19.3	MFS	uniport; Na⁺ symport	An
Acylcarnitine	2.A.29.8.1	MC	solute:solute antiport	Mito
S-Adenosylmethionine	2.A.3.10.15	APC	H⁺ symport	Y
Amines, organic (nonspecific)	2.A.1.19.1-5	MFS	uniport?	An
g-Aminobutyrate	2.A.3.4.2	APC	H⁺ symport	Fu, Y
g-Aminobutyrate	2.A.3.7.1	APC	H⁺ symport	B
Auxin	2.A.18.1.1	AAAP	H⁺ symport	Pl
Auxin	2.A.69.1.1-2	AEC	uniport; H⁺ antiport?	Pl
Betaine	2.A.1.6.4	MFS	H⁺/Na⁺ symport	B
Betaine	2.A.23.3.1	SSS	Na⁺ symport	An
Butyrobetaine	2.A.1.19.3	MFS	uniport; Na⁺ symport	An
Cadaverine	2.A.3.2.2	APC	antiport with lysine	B
Carnitine	2.A.1.19.3	MFS	uniport; Na⁺ symport	An
	2.A.15.2.1	BCCT	H⁺ symport	B
	2.A.29.8.1	MC	solute:solute antiport	Mito
Choline	2.A.3.4.1	APC	H⁺ symport?	Y
Choline	2.A.15.3.1	BCCT	H⁺ symport	B
2.A.22.3.5	NSS	Na⁺ symport	An
Creatine	2.A.22.3.4	NSS	Na⁺ symport	An
Dopamine	2.A.1.22.1	MFS	?	An
Dopamine	2.A.22.1.3	NSS	Na⁺ symport	An
Ectosine	2.A.15.1.2	BCCT	H⁺ symport	B
Ethanolamine	2.A.3.5.1	APC	H⁺ symport	B
Glycine betaine	2.A.1.6.4	MFS	H⁺,Na⁺ symport	B
	2.A.1.19.3	MFS	uniport; Na⁺ symport	An
	2.A.15.1.1-2	BCCT	H⁺ symport	B
	2.A.22.3.1	NSS	Na⁺ symport	An
Guanidinium	2.A.1.19.2	MFS	H⁺ antiport	An
Monoamines	2.A.1.2.11	MFS	H⁺ antiport	An
Monoamines	2.A.1.2.12	MFS	H⁺ antiport	An
Neurotransmitters (cationic)	2.A.1.19.1	MFS	uniport?	An
	2.A.1.19.5-7	MFS	uniport?	An
	2.A.1.22.1	MFS	uniport or H⁺ or Na⁺ symport	An
Noradrenaline	2.A.22.1.2	NSS	Na⁺ symport	An
Organic cations	2.A.1.19.1-5	MFS	uniport or H⁺ or Na⁺ symport	An
Polyamines (efflux)	2.A.1.2.16	MFS	H⁺ antiport	An
Putrescine	2.A.3.2.1	APC	H⁺ symport; antiport with ornithine	B
Quaternary amines	2.A.77.1.2	CadD	H⁺ antiport?	B
Serotonin	2.A.22.1.1	NSS	Na⁺ symport	An
Taurine	2.A.22.3.3	NSS	Na⁺ symport	An
Tetramethyl ammonium	2.A.1.19.1	MFS	H⁺ antiport; uniport?	An
Urea	2.A.21.6.1	SSS	?	Y

Glycopeptides, cell-wall derived	2.A.1.25.2	MFS	H⁺ symport?	B
Peptides	2.A.17.1-4	POT	H⁺ symport	B, E
	2.A.67.1-2	OPT	H⁺ symport?	B, A, Y, Pl
	9.A.18	PUP	?	B
Peptides, antibacterial (efflux)	2.A.6.2.5	RND	H⁺ antiport	B
Peptides, cell-wall derived	2.A.1.25.2	MFS	H⁺ symport?	B

Allantoin	2.A.39.3.1	NCS1	H⁺ symport	Y
Cytosine	2.A.39.1.1	NCS1	H⁺ symport	B
Cytosine	2.A.39.2.1	NCS1	H⁺ symport	Y
Nucleobases	2.A.74.1.1	MET	H⁺ antiport?	An
Purines	2.A.39.2.1	NCS1	H⁺ symport	Y
	2.A.40.2.1	NCS2	H⁺ symport	B
	2.A.40.5.1	NCS2	H⁺ symport	Fu
Uracil	2.A.39.3.2	NCS1	H⁺ symport	Y
Uracil	2.A.40.1.1	NCS2	H⁺ symport	B
Uric acid	2.A.40.4.1	NCS2	H⁺ symport	Fu
Xanthine	2.A.40.3.1	NCS2	H⁺ symport	B
Xanthine	2.A.40.4.1	NCS2	H⁺ symport	Fu

Nucleosides	2.A.1.10.1	MFS	H⁺ symport	B
	2.A.21.3.3	SSS	Na⁺ symport	An
	2.A.41.1.1	CNT	H⁺ symport	B
	2.A.41.2.2-5	CNT	Na⁺ symport	An
	2.A.57.1-3	ENT	uniport	Y, Pr, An
	2.A.74.1.1	MET	H⁺ antiport?	An
	9.A.6.1.1	INT	?	An
Nucleosides (pyrimidine-specific)	2.A.41.1.2	CNT	Na⁺ symport	B
Nucleosides (purine-specific)	2.A.41.2.1	CNT	Na⁺ symport	An
Uridine	2.A.39.3.2-3	NCS1	H⁺ symport	Y
Xanthosine	2.A.1.10.2	MFS	H⁺ symport	B

ADP	2.A.12.1.1-2	AAA	solute:solute antiport	B
	2.A.12.2.1	AAA	solute:solute antiport	Pl
	2.A.29.1.1	MC	solute:solute antiport	Mito
ATP	2.A.12.1.1	AAA	solute:solute antiport	B
	2.A.12.1.2	AAA	solute:solute antiport	Pl
	2.A.29.1.1	MC	solute:solute antiport	Mito
Nucleoside triphosphates	2.A.12.3.1	AAA	H⁺ symport	B

L-Ascorbate	2.A.40.6.1	NCS2	Na⁺ symport	An
p-Aminobenzoylglutamate	2.A.68.1.1	AbgT	H⁺ symport	B
Anionic vitamins	2.A.21.5.2	SSS	Na⁺ symport	An
Biopterin	2.A.71.1.1-4	FBT	H⁺ symport?	Pr
Biotin	2.A.21.5.2	SSS	Na⁺ symport	An
Cationic vitamins	2.A.1.19.1	MFS	uniport	An
Flavin adenine dinucleotide	2.A.29.10.1	MC	?	Mito
Folate (reduced)	2.A.48.1.1	RFC	H⁺ symport	An
Folate	2.A.71.1.1-4	FBT	H⁺ symport?	Pr
5-Formyltetrahydrofolate	2.A.48.1.1	RFC	Na⁺ symport?	An
Lipoate	2.A.21.5.2	SSS	Na⁺ symport	An
Nicotinate	2.A.65.1.1	BRT	H⁺ symport	An
Panthothenate	2.A.21.1.1	SSS	Na⁺ symport	B
Panthothenate	2.A.21.5.2	SSS	Na⁺ symport	An
Tetrahydrofolate	2.A.48.1.1	RFC	Na⁺ symport?	An
Thiamine	2.A.39.4.1	NCS1	H⁺ symport	Y
Thiamine	2.A.48.2.1	RFC	Na⁺ symport?	An

Acetyl coenzyme A	2.A.1.25.1	MFS	solute:solute antiport	An (ER)
S-Adenosylmethionine	2.A.3.10.15	APC	H⁺ symport	Y
CMP-sialate	2.A.50.7.1	TP-NST	CMP antiport	An (ER)
Coenzyme A	2.A.1.25.1	MFS	solute:solute antiport	An (ER)
Flavin adenine dinucleotide	2.A.29.10.1	MC	?	Mito
GDP-mannose	2.A.50.8.1	TP-NST	GMP antiport	An, Y (ER)
Nicotinamide mononucleotide	9.A.4.1.1	PnuC	?	B
UDP-N-acetylglucosamine	2.A.50.5.1	TP-NST	UMP antiport	Y, An (ER)
UDP-galactose	2.A.50.6.1	TP-NST	UMP antiport	An (ER)

Fe-enterobactin	2.A.1.16.2	MFS	H⁺ symport?	Y
Fe-ferrioxamine	2.A.1.16.1	MFS	H⁺ symport?	Y
Fe-siderophore	2.A.1.16.1	MFS	H⁺ symport?	Y
Fe-triacetylfusarinine	2.A.1.16.3	MFS	H⁺ symport?	Y

Acyl L-homoserine lactone	2.A.6.2.6	BRND	H⁺ antiport	B
Isoflavonoids	2.A.6.2.3	RND	H⁺ antiport	B
Nodulation factor	2.A.6.3.1	RND	H⁺ antiport	B
Prostaglandins	2.A.60.1.2	OAT	?	An
Steroid hormones	2.A.1.19.4	MFS	?	An
Steroid hormones	2.A.6.6	RND	?	An, Y
Thyroid hormones (thyroxine, triiodothyronine)	2.A.60.1.3, -7	OAT	?	An

Multiple drugs	2.A.1.2.5	MFS	H⁺ antiport	B
	2.A.1.2.6	MFS	H⁺ antiport	Y
	2.A.1.2.7	MFS	H⁺ antiport	B
	2.A.1.2.8	MFS	H⁺ antiport	B
	2.A.1.2.9	MFS	H⁺ antiport	B
	2.A.1.2.10	MFS	H⁺ antiport	B
	2.A.1.2.11-12	MFS	H⁺ antiport	An
	2.A.1.2.16-17	MFS	H⁺ antiport	An
	2.A.1.3.1	MFS	H⁺ antiport	Y
	2.A.1.3.2	MFS	H⁺ antiport	B
	2.A.1.3.3	MFS	H⁺ antiport	B
	2.A.1.3.4	MFS	H⁺ antiport	B
	2.A.1.3.5	MFS	H⁺ antiport	B
	2.A.1.21.1-4	MFS	H⁺ antiport	B
	2.A.6.2.1-2, -6	RND	H⁺ antiport	B
Multiple drugs (cationic)	2.A.1.19.1	MFS	uniport	An
Multiple drugs (aminoglycosides)	2.A.1.20.1	MFS	H⁺ antiport?	B
Multiple drugs and dyes (cationic)	2.A.7.1.1-2	SMR	H⁺ antiport	B
Multiple drugs (antibiotics) (uptake)	2.A.17.4.1	POT	H⁺ symport	An
Multiple drugs (antibiotics) (uptake)	2.A.1.25.2	MFS	H⁺ symport	B
Multiple drugs (antibiotics)	2.A.66.1-3	MATE	H⁺ antiport	B, Y
Multiple drugs (antibiotics)	2.A.74.1.1-2	MET	H⁺ antiport?	An
Xenobiotics	2.A.1.19.1	MFS	uniport	An

Acriflavin	2.A.1.2.8	MFS	H⁺ antiport	B
Acriflavin	2.A.1.3.3	MFS	H⁺ antiport	B
Actinorhodin	2.A.1.3.7	MFS	H⁺ antiport	B
Actinorhodin	2.A.6.5.1	RND	H⁺ antiport	B
Amiloride	2.A.1.2.1	MFS	H⁺ antiport	Y
Aminoglycosides	2.A.1.20.1	MFS	H⁺ antiport?	B
Aminotriazole	2.A.1.3.1	MFS	H⁺ antiport	Y
Ampicillin (in)	2.A.1.25.2	MFS	H⁺ symport?	B
Benomyl	2.A.1.2.6	MFS	H⁺ antiport	Y
Bicyclomycin	2.A.1.2.7	MFS	H⁺ antiport	B
Bile acids	2.A.1.3.13	MFS	H⁺ antiport	B
Bleomycin	2.A.1.21.2	MFS	H⁺ antiport	B
Carbonylcyanide m-chlorophenylhydrazone (CCCP)	2.A.1.2.9	MFS	H⁺ antiport	B
Carbonylcyanide m-chlorophenylhydrazone (CCCP)	2.A.1.3.2	MFS	H⁺ antiport	B
Cephamycin	2.A.1.3.8	MFS	H⁺ antiport	B
Chloramphenicol	2.A.1.2.3	MFS	H⁺ antiport	B
Chloramphenicol	2.A.1.2.8	MFS	H⁺ antiport	B
Cycloheximide	2.A.1.2.2	MFS	H⁺ antiport	Y
Cycloheximide	2.A.1.2.6	MFS	H⁺ antiport	Y
Daunomycin	2.A.1.2.5	MFS	H⁺ antiport	B
Daunorubicin	2.A.1.2.11	MFS	H⁺ antiport	An
Erythromycin	2.A.1.21.1	MFS	H⁺ antiport	B
Ethidium bromide	2.A.1.2.5	MFS	H⁺ antiport	B
	2.A.1.2.8	MFS	H⁺ antiport	B
	2.A.1.2.11	MFS	H⁺ antiport	An
	2.A.1.3.3	MFS	H⁺ antiport	B
	2.A.66.1.1	MATE	H⁺ antiport	B
Ethionine	2.A.66.3.1	MATE	H⁺ antiport	Y
Fluconazole	2.A.1.2.17	MFS	H⁺ antiport	Y
Fluoroquinolones	2.A.1.2.8	MFS	H⁺ antiport	B
Fluoroquinolones	2.A.1.3.3	MFS	H⁺ antiport	B
Hydrophobic uncouplers	2.A.1.2.9	MFS	H⁺ antiport	B
Isoflavonoid	2.A.6.2.3	RND	H⁺ antiport	B
Kanamycin	2.A.1.20.1	MFS	H⁺ antiport?	B
Kanamycin	2.A.66.1.1	MATE	H⁺ antiport	B
b-Lactams (uptake)	2.A.17.4.1	POT	H⁺ symport	An
Lincomycin	2.A.1.3.9	MFS	H⁺ antiport	B
Macrolides	2.A.1.21.1	MFS	H⁺ antiport	B
Methotrexate	2.A.1.2.6	MFS	H⁺ antiport	Y
	2.A.48.1.1	RFC	Na⁺ symport?	An
	2.A.60.1.4	OAT	?	An
Methylenomycin	2.A.1.3.10	MFS	H⁺ antiport	B
Methylviologen	2.A.1.3.14	MFS	H⁺ antiport	B
Nalidixic acid	2.A.1.3.2	MFS	H⁺ antiport	B
4-Nitroquinoline N-oxide	2.A.1.3.1	MFS	H⁺ antiport	Y
Norfloxacin	2.A.66.1.1	MATE	H⁺ antiport	B
Oleandomycin	2.A.1.21.1	MFS	H⁺ antiport	B
Organocations	2.A.1.3.4	MFS	H⁺ antiport	B
Organomercurials	2.A.1.3.2	MFS	H⁺ antiport	B
Paraquat	2.A.1.2.16	MFS	H⁺ antiport	Y
Penicillin and derivatives (in)	2.A.1.25.2	MFS	H⁺ symport	B
Pristinamycin	2.A.1.3.5	MFS	H⁺ antiport	B
Puromycin	2.A.1.3.11	MFS	H⁺ antiport	B
Puromycin	2.A.1.21.2	MFS	H⁺ antiport	B
Quinoline	2.A.1.2.10	MFS	H⁺ antiport	B
Rifamycin	2.A.1.3.5	MFS	H⁺ antiport	B
Rifamycin	2.A.1.3.15	MFS	H⁺ antiport	B
Streptomycin	2.A.1.20.1	MFS	H⁺ antiport?	B
Streptomycin	2.A.66.1.1	MATE	H⁺ antiport	B
Sulfathiazole	2.A.1.27	MFS	H⁺ antiport	B
Tetracenomycin	2.A.1.3.12	MFS	H⁺ antiport	B
Tetracycline	2.A.1.2.4	MFS	H⁺ antiport	B
	2.A.1.3.6	MFS	H⁺ antiport	B
	2.A.1.21.2-3	MFS	H⁺ antiport	B

Steroids	2.A.6.2.5	RND	H⁺ antiport	B
Sterols (nonspecific)	2.A.1.19.4	MFS	uniport; H⁺ symport	An
Sterols (nonspecific)	2.A.74.1.1	MET	H⁺ antiport?	An
Sterols (probably nonspecific)	2.A.6.6.1, -3	RND	H⁺ antiport?	Y, An
Aldosterone	2.A.6.6.1, -3	RND	H⁺ antiport?	Y, An
Cardiac glycosides	2.A.6.6.1, -3	RND	H⁺ antiport?	Y, An
Cortisol	2.A.6.6.1, -3	RND	H⁺ antiport?	Y, An
Dexamethasone	2.A.6.6.1, -3	RND	H⁺ antiport?	Y, An
Estrone 3-sulfate	2.A.6.6.1, -3	RND	H⁺ antiport?	Y, An
Estradiol 17-glucuronide	2.A.6.6.1, -3	RND	H⁺ antiport?	Y, An
Ouabain	2.A.6.6.1, -3	RND	H⁺ antiport?	Y, An
Steroid conjugates	2.A.6.6.1, -3	RND	H⁺ antiport?	Y, An
Steroid hormones (conjugates and nonconjugates)	2.A.60.1	OAT	?	An

Lipooligosaccharides	2.A.6.3.1	RND	H⁺ antiport?	B
Exo- and capsular polysaccharides (out)	9.A.1.2.1-2	PST	H⁺ antiport?	B
Lipopolysaccharide (out)	9.A.1.1	PST	H⁺ antiport?	B

Proteins (nonspecific)	2.A.6.4.1	RND, SecDF	H⁺ antiport?	B, A
Proteins (nonspecific)	2.A.9	Oxa1	?	B, E
Redox enzymes/proteins	2.A.64.1.1	TAT	PMF-driven	B, A, E