Classification of Membrane Transport Proteins

Continued from class 3

Classification of Transport Proteins According to Substrate Specificity

4. Primary Active Transporters (excluding Macromolecular Transporters)


I.C.1. Inorganic cations: univalent
I.C.2. Inorganic cations: divalent and tervalent
I.D. Inorganic anions
II.A. Sugars and polyols
II.B. Fatty acids
II.D. Organic anions: phosphates, phosphonates, sulfonates (uptake)
III.A. Amino acids and derivatives (uptake)
III.C. Peptides
V.A. Vitamins
V.B. Enzyme and redox cofactors
V.C. Siderophores and Fe-siderophore complexes
VI.A. Multiple drugs (mostly efflux)
VI.B. Specific drugs (mostly efflux)
VI.C. Bile salts and conjugates
VI.D. Sterols and conjugates

I.C.1. Inorganic cations: univalent

Substrate (polarity)TC numberFamilyEnergy sourceDistributiona
H+ (both ways) 3.A.2.1.1, -3F-ATPase ATP B, Mito, Chloro
3.D.2.1-4 PTH hydride transfer B, Mito
H+ (out) 3.A.2.2.1 F (V)-ATPaseATP B, E
3.A.3.3.1 P-ATPase ATP A, E
3.D.1.1.1-3 NDH electron flow B, Mito
3.D.3.1-5 QCR electron flow B, Mito, Chloro
3.D.4.1-7 COX electron flow B, A, Mito
3.D.7.1.1 HHO electron flow A
3.D.8.1.1 FMF-DHelectron flow A
3.E.1.1.1 and 3FAR light-driven A
3.E.2.2.1-2PRC light-driven B, Chloro
H+ (out)?3.A.2.3.1 F (A)-ATPase ATP A
3.A.3.1.2 P-ATPaseATP An
H+ (into vacuoles) 3.A.10.1.1 H+-PPase diphosphate B, Pl
H+ (in?) or Na+ (in?)3.D.6.1.1 NFO electron flow B
K+ (in)3.A.3.1.1 P-ATPase ATP An
3.A.3.1.2 P-ATPase ATP An
3.A.3.3.1 P-ATPase ATP Pr, Fu, Pl
3.A.3.7.1 P-ATPase ATP B
Na+ (both ways) 3.A.2.1.2 F-ATPase ATP B
Na+ (out) 3.A.1.115.1 ABC ATP B
3.A.2.2.2 F (V)-ATPaseATP B
3.A.3.1.1 P-ATPase ATP An
3.A.3.9.1 P-ATPaseATP Y
3.B.1.1.1 NaT-DCoxaloacetate
3.B.1.1.2 NaT-DCmethylmalonyl-CoA
3.B.1.1.3 NaT-DCglutaconyl-CoA
3.B.1.1.4 NaT-DC malonate
3.D.1.1.1NDH electron flow B, Mito
3.D.5.1.1 Na-NDH electron flow B
3.D.8.1.1 FMF-DH electron flow A
3.C.1.1.1NaT-MMMmethyl transfer A
Ca2+ (out)3.A.3.2.1-4; 1.B.2P-ATPase ATP B, E
Cd2+ (out) 3.A.1.207.1 ABC ATP Y
3.A.3.6.1-2 P-ATPase ATP B, Fu, Pl, Pr
Co2+ (in) 3.A.1.18.1 ABC ATP B
Co2+ (out)3.A.3.6.2 P-ATPaseATP B
Cu2+ (in) 3.A.3.5.1 P-ATPase ATP B, E
Cu2+ (out) 3.A.3.5.2-3 P-ATPase ATP B, E
Fe3+ (in) 3.A.1.10.1 ABC ATP B
3.A.1.15.4, -6 ABC ATP B
3.A.1.20.1 ABC ATP B
9.A.8.1.1 FeoB ATP or PMF(?) B
Fe chelates 3.A.1.14.1-5 ABC ATP B
Metal conjugates (out) 3.A.1.203 and 210ABC ATP Y, An
Mg2+ (in) 3.A.3.4.1 P-ATPaseATP B
Mn2+ (in)3.A.1.15.1 ABC ATP B
Mn2+ (out) 3.A.3.2.3 P-ATPase ATP Y
Ni2+ (in) 3.A.1.5.3 ABC ATP B
Ni2+ (out) 3.A.3.6.2 P-ATPase ATP B
Pb2+ (out) 3.A.3.6.2 P-ATPase ATP B
Zn2+ (in) 3.A.1.15.2-3, -5-6 ABC ATP B
Zn2+ (out) 3.A.3.6.1-2 P-ATPase ATP B

I.D. Inorganic anions

Antimonite (out) 3.A.4.1.1 ArsAB ATP B
Arsenite (out) 3.A.4.1.1 ArsAB ATP B
Bicarbonate (in) 3.A.1.16.3ABC ATP B
Chloride (in) 3.E.1.2.1 FAR
Chloride (none) 3.A.1.62.1 ABC (CFTR) channel (ATP-activated) An
Cyanate (in) 3.A.1.16.2 ABC ATP B
Molybdate (in) 3.A.1.8.1ABC ATP B
Nitrate (in) 3.A.1.16.1 ABC ATP B
Nitrite (in) 3.A.1.16.1 ABC ATP B
Phosphate (in) 3.A.1.7.1 ABC ATP B
Sulfate (in) 3.A.1.6.1 ABC ATP B
Tellurite (out)3.A.4.1.1 Ars ATP B
Thiosulfate (in) 3.A.1.6.1 ABC ATP B

II.A. Sugars and polyols

N-Acetylgalactosamine 4.A.6.1.4 PTS PEP B
N-Acetylglucosamine4.A.1.1.2PTS PEP B
4.A.6.1.1-2 PTS PEP B
Allose 3.A.1.2.6 ABC ATP B
Arabinose 3.A.1.2.2 ABC ATP B
3.A.1.2.5ABC ATP B
Arbutin 4.A.1.2.2-3 PTS PEP B
Cellobiose 4.A.1.2.2-3 PTS PEP B
4.A.3.1.2 PTS PEP B
Cyclodextrins 3.A.1.1.6 ABC ATP B
Diacetylchitobiose 4.A.3.2.1 PTS PEP B
Fructose 4.A.2.1.1 PTS PEP B
4.A.6.1.1-2 PTS PEP B
Fucose 3.A.1.2.5 ABC ATP B
Galactitol 4.A.5.1.1 PTS PEP B
Galactose 3.A.1.2.3 ABC ATP B
3.A.1.2.5 ABC ATP B
Glucitol 3.A.1.1.5 ABC ATP B
4.A.4.1.1 PTS PEP B
Glucosamine 4.A.6.1.1-2 PTS PEP B
Glucose 3.A.1.2.3 ABC ATP B
3.A.1.2.5 ABC ATP B
4.A.1.1.1 PTS PEP B
4.A.6.1.1-2 PTS PEP B
b-Glucosides 4.A.1.2.2-3 PTS PEP B
Lactose 3.A.1.1.4 ABC PEP B
4.A.3.1.1 PTS PEP B
Lichenan oligosaccharides 4.A.3.2.2 PTS PEP B
Maltooligosaccharides 3.A.1.1.1 ABC ATP B
Maltose 3.A.1.1.1, -7, -8ABC ATP B
4.A.1.1.3 PTS PEP B
Mannitol 3.A.1.1.5 ABC ATP B
4.A.2.1.2 PTS PEP B
Mannose 4.A.6.1.1-2PTS PEP B
Melibiose 3.A.1.1.2 ABC ATP B
Multiple sugars 3.A.1.1.2, -2.5, -3.1ABC ATP B
Raffinose 3.A.1.1.2 ABC ATP B
Ribose 3.A.1.2.1 ABC PEP B
Salicin 4.A.1.2.2-3 PTS PEP B
Sorbose 4.A.6.1.3 PTS PEP B
Sucrose 3.A.1.1.8 ABC ATP B
4.A.1.2.1 PTS PEP B
Trehalose 3.A.1.1.7-8ABC ATP B
4.A.1.2.4 PTS PEP B
Xylose 3.A.1.2.4 ABC ATP B
3.A.1.2.5 ABC ATP B

II.B. Fatty acids

Fatty acids (long-chain) 3.A.1.203.1-2ABC ATP An, Y

II.D. Organic anions: phosphates, phosphonates, sulfonates (uptake)

2-Aminoethyl phosphonate 3.A.1.11.5 ABC ATP B
2-Aminoethyl sulfonate (taurine)3.A.1.17.1 ABC ATP B
Glucuronate 3.A.1.1.9 ABC ATP B
Glycerol phosphate 3.A.1.1.3 ABC ATP B
Phosphates (organic) 3.A.1.9.1 ABC ATP B
Phosphonates (organic) 3.A.1.9.1 ABC ATP B
Taurine 3.A.1.17.1 ABC ATP B

III.A. Amino acids and derivatives (uptake)

Agrocinopine 3.A.1.5.4 ABC ATP B
Arginine 3.A.1.3.1, -3, -11ABC ATP B
Asparagine 3.A.1.3.7 ABC ATP B
Aspartate 3.A.1.3.4 ABC ATP B
3.A.1.3.7ABS ATP B
Chrysopine 3.A.1.11.4 ABC ATP B
Cystine 3.A.1.3.10 ABC ATP B
Diaminopimelate 3.A.1.3.10ABC ATP B
General L-amino acids 3.A.1.3.8 ABC ATP B
Glutamate 3.A.1.3.4 ABC ATP B
3.A.1.3.7 ABC ATP B
3.A.1.3.9 ABC ATP B
Glutamine 3.A.1.3.2 ABC ATP B
3.A.1.3.7 ABC ATP B
Glycine betaine
3.A.1.12.1-2 ABC ATP B
3.A.1.12.4 ABC ATP B
Histidine 3.A.1.3.1 ABC ATP B
Isoleucine 3.A.1.4.1 ABC ATP B
Leucine 3.A.1.4.1 ABC ATP B
Lysine 3.A.1.3.1 ABC ATP B
Mannopine 3.A.1.11.3 ABC ATP B
Nopaline 3.A.1.3.6 ABC ATP B
Octopine 3.A.1.3.5 ABC ATP B
Ornithine 3.A.1.3.1, -11ABC ATP B
Proline 3.A.1.12.1 ABC ATP B
Valine 3.A.1.4.1 ABC ATP B

III.B. Amines, amides, and polyamines (uptake)

g-Butyrobetaine3.A.1.12.1,-4 ABC ATP B
D- and L-carnitine 3.A.1.12.1, -4 ABC ATP B
Choline 3.A.1.12.1, -3-4 ABC ATP B
Choline-O-sulfate3.A.1.12.4 ABC ATP B
Crotonobetaine 3.A.1.12.4 ABC ATP B
Dimethylproline 3.A.1.12.1 ABC ATP B
Ectoine 3.A.1.12.4 ABC ATP B
Glycine betaine 3.A.1.12.1-2, -4 ABC ATP B
Homobetaine 3.A.1.12.1 ABC ATP B
Polyamines 3.A.1.11.1 ABC ATP B
Proline betaine 3.A.1.12.1 ABC ATP B
Putrescine 3.A.1.11.1-2 ABC ATP B
Quaternary amines3.A.1.12.1-5 ABC ATP B
Spermidine 3.A.1.11.1ABC ATP B

III.C. Peptides

a-Factor (sex pheromone) (out) 3.A.1.206.1 ABC ATP Y
Cationic peptides (in) 3.A.1.5.5 ABC ATP B
Cyclic peptides (out) 3.A.1.113.1 ABC ATP B
Dipeptides (in) 3.A.1.5.2 ABC ATP B
Glutathione (oxidized) (out) 3.A.1.207.1, 208.2 ABC ATP An
Glutathione conjugates (out)3.A.1.207.1 ABC ATP An
MHC peptides (out) 3.A.1.209.1ABC ATP An, Y
Oligopeptides (in) 3.A.1.5.1 ABC ATP B
Peptide antibiotics (in) 3.A.1.5.5 ABC ATP B
Peptides (out) 3.A.1.111-113,
  -116, -118
3.A.1.201.1 ABC ATP An
Protamines 3.A.1.5.5 ABC ATP B

V.A. Vitamins

Thiamine 3.A.1.19.1 ABC ATP B
Vitamin B12 (uptake) 3.A.1.13.1 ABC ATP B

V.B. Enzyme and redox cofactors

Eye pigment (export) 3.A.1.204.1 ABC ATP An
Fatty acyl coenzyme A 3.A.1.203.1-2 ABC ATP Y, An peroxisomes
Heme (hemin) (uptake) 3.A.1.14.5 ABC ATP B
Heme (hemin) (export) 3.A.1.107.1 ABC ATP B
Thiamine diphosphate 3.A.1.19.1 ABC ATP B

V.C. Siderophores and Fe-siderophore complexes

Fe-aerobactin 3.A.1.14.3 ABC ATP B
Fe chelates (many) 3.A.1.15.4 ABC ATP B
Fe-chrysobactin 3.A.1.14.4 ABC ATP B
Fe-coprogen 3.A.1.14.3 ABC ATP B
Fe-dicitrate 3.A.1.14.1 ABC ATP B
Fe-enterobactin 3.A.1.14.2 ABC ATP B
Fe-ferrichrome 3.A.1.14.3 ABC ATP B
Fe-ferrioxamine 3.A.1.14.3 ABC ATP B
Fe-hydroxamate 3.A.1.14.3 ABC ATP B
Siderophores (export) 3.A.1.113, -119 ABC ATP B

VI.A. Multiple drugs (mostly efflux)

Agrocin 84 (uptake) 3.A.1.5.4 ABC ATP B
Aminoglycoside antibiotics
3.A.1.5.1 ABC ATP B
Multiple drugs 3.A.1.108,
  -117, -119
  -205, -208, -210
ABC ATP B, Fu, Y, An

VI.B. Specific drugs (mostly efflux)

Albomycin (uptake) 3.A.1.14.3 ABC ATP G-
Daunorubicin 3.A.1.105.1 ABC ATP G+ B
Doxorubicin 3.A.1.105.1 ABC ATP G+ B
Erythromycin 3.A.1.105.4 ABC ATP G+ B
Lantibiotics 3.A.1.114.1 ABC ATP G-
Macrolides 3.A.1.105.3 ABC ATP G+ B
Microcin B17 3.A.1.116.1 ABC ATP G-
Oleandomycin 3.A.1.105.2 ABC ATP G+ B
Oligomycin 3.A.1.208.3 ABC ATP Y
Syringomycin 3.A.1.113.1 ABC ATP G-
Tylosin 3.A.1.105.5 ABC ATP G+ B

VI.C. Bile salts and conjugates

Bile salts 3.A.1.207.2, -208.2 ABC ATP An
Bilirubin 3.A.1.208.2 ABC ATP An
Bilirubin glucuronides 3.A.1.208.2 ABC ATP An
Glucuronides 3.A.1.208.2 ABC ATP An
Glutathione conjugates 3.A.1.207.1 ABC ATP Y
3.A.1.208.1-2 ABC ATP An
Leukotrienes 3.A.1.208.1-2 ABC ATP An

VI.D. Sterols and conjugates

Steroids (export) 3.A.1.205.1 ABC ATP Y

a Abbreviations used for types of organisms, organelles and viruses are as follows: B, Bacteria; A, Archaea; E, Eucarya; G-, Gram-negative bacteria; G+, Gram-positive bacteria; Y, yeasts; Fu, fungi; Pr, protozoans; Pl, plants; An, animals; Mito, mitochondria; Chloro, chloroplasts; ER, endoplasmic reticulum; Bp, bacteriophage; V, virus

Continued with Class 5
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