1-Carboxyvinyl Group

Enzyme Nomenclature: The group -C(COOH)=CH2 in chorismate and UDP-muramate synthesis

From the JCBN/NC-IUB Newsletter 1983 [1]

The 1-carboxyvinyl group has been given various names base on pyruvate in the past. These are misleading because they imply the presence of oxygen on the central carbon atom, and because they suggest that the group is an acyl group. By contrast, the carboxymethyl group is not named as a derivative of acetate. NC-IUB therefore, despite its great reluctance to change existing names, believes that it will be much less confusing to give this group its systematic name of 1-carboxyvinyl. This leads to revised entries for four enzymes in Supplement 4:

EC 1.1.1.158UDPacetylmuramate dehydrogenase
EC 2.5.1.7UDPacetylglucosamine 1-carboxyvinyltransferase
EC 2.5.1.193-Phosphoshikimate 1-carboxyvinyltransferase
EC 4.6.1.4Chorismate synthase
1. IUPAC-IUB Joint Commission on Biochemical Nomenclature (JCBN), and Nomenclature Commission of IUB (NC-IUB), Newsletter 1983, Arch. Biochem. Biophys., 1983, 220, 321-324; Biochem. Internat., 1983, 6, following p 128; Biochem. J., 1983, 209, I-IV; Canad. J. Biochem. Cell Biol., 1983, 61, v-ix; Eur. J. Biochem., 1983, 131, 1-3; Hoppe-Seyler's Z. Physiol. Chem., 1983, 364, I-IV; Trends Biochem. Sci., 1983, 8, various issues.

Note The reference to Enzyme Nomenclature and Supplement 4 refers to the 1978 edition not the 1992 edition. Current entries which involve this group are:

EC 1.1.1.158UDP-N-acetylmuramate dehydrogenase
EC 2.5.1.7UDP-N-acetylglucosamine 1-carboxyvinyltransferase
EC 2.5.1.193-phosphoshikimate 1-carboxyvinyltransferase
EC 2.7.8.23carboxyvinyl-carboxyphosphonate phosphorylmutase
EC 4.2.3.5chorismate synthase (formerly EC 4.6.1.4)

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