Reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate
For diagram click here, click here, (another example) and (another example) (mechanism).
Other name(s): transaminase B; branched-chain amino acid aminotransferase; branched-chain amino acid-glutamate transaminase; branched-chain aminotransferase; L-branched chain amino acid aminotransferase; glutamate-branched-chain amino acid transaminase
Systematic name: branched-chain-amino-acid:2-oxoglutarate aminotransferase
Comments: Also acts on L-isoleucine and L-valine, and thereby differs from EC 2.6.1.6, leucine transaminase, which does not. It also differs from EC 2.6.1.66, valine—pyruvate transaminase.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9054-65-3
References:
1. Aki, K., Ogawa, K. and Ichihara, A. Transaminases of branched chain amino acids. IV. Purification and properties of two enzymes from rat liver. Biochim. Biophys. Acta 159 (1968) 276-284. [PMID: 4968655]
2. Aki, K., Yokojima, A. and Ichihara, A. Transaminase of branched chain amino acids. VI. Purification and properties of the hog brain enzyme. J. Biochem. (Tokyo) 65 (1969) 539-544. [PMID: 4979711]
3. Ichihara, A. and Koyama, E. Transaminase of branched chain amino acids. I. Branched chain amino acids-α-ketoglutarate transaminase. J. Biochem. (Tokyo) 59 (1966) 160-169. [PMID: 5943594]
4. Taylor, R.T. and Jenkins, W.T. Leucine aminotransferase. II. Purification and characterization. J. Biol. Chem. 241 (1966) 4396-4405. [PMID: 5922965]
5. Rudman, D. and Meister, A. Transamination in Escherichia coli. J. Biol. Chem. 200 (1953) 591-604.