IUBMB Enzyme Nomenclature

EC 2.7.1.119

Accepted name: hygromycin-B 7"-O-kinase

Reaction: ATP + hygromycin B = ADP + 7"-O-phosphohygromycin B

For diagram click here

Other name(s): hygromycin B phosphotransferase; hygromycin-B kinase (ambiguous)

Systematic name: ATP:hygromycin-B 7"-O-phosphotransferase

Comments: Phosphorylates the antibiotics hygromycin B, 1-N-hygromycin B and destomycin, but not hygromycin B2, at the 7"-hydroxy group in the destomic acid ring.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 88361-67-5

References:

1. Zalacain, M., Pardo, J.M. and Jiménez, A. Purification and characterization of a hygromycin B phosphotransferase from Streptomyces hygroscopicus. Eur. J. Biochem. 162 (1987) 419-422. [PMID: 3026811]

[EC 2.7.1.119 created 1989, modified 2009, modified 2011]


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