IUBMB Enzyme Nomenclature


Accepted name: diphosphate-purine nucleoside kinase

Reaction: diphosphate + a purine nucleoside = phosphate + a purine mononucleotide

Other name(s): pyrophosphate-purine nucleoside kinase

Systematic name: diphosphate:purine nucleoside phosphotransferase

Comments: the enzyme from the Acholeplasma class of Mollicutes catalyses the conversion of adenosine, guanosine and inosine to AMP, GMP and IMP. ATP cannot substitute for diphosphate as a substrate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 70356-41-1


1. Tryon, V.V., Pollack, D. Purine metabolism in Acholeplasma laidlawii B: novel PPi-dependent nucleoside kinase activity. J. Bacteriol. 159 (1984) 265-270. [PMID: 6330034]

2. Tryon, V.V., Pollack, J.D. Distinctions in Mollicutes purine metabolism: pyrophosphate-dependent nucleoside kinase and dependence on guanylate salvage. Int. J. Systematic Bacteriol. 35 (1985) 497-501.

[EC created 1999]

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