IUBMB Enzyme Nomenclature


Accepted name: autoinducer-2 kinase

Reaction: ATP + (S)-4,5-dihydroxypentane-2,3-dione = ADP + (S)-4-hydroxypentane-2,3-dione 5-phosphate

Glossary: (S)-4,5-dihydroxypentane-2,3-dione = autoinducer 2 = AI-2

Other name(s): lsrK (gene name)

Systematic name: ATP:(S)-4,5-dihydroxypentane-2,3-dione 5-phosphotransferase

Comments: The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number:


1. Xavier, K.B., Miller, S.T., Lu, W., Kim, J.H., Rabinowitz, J., Pelczer, I., Semmelhack, M.F. and Bassler, B.L. Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria. ACS Chem. Biol. 2 (2007) 128-136. [PMID: 17274596]

2. Roy, V., Fernandes, R., Tsao, C.Y. and Bentley, W.E. Cross species quorum quenching using a native AI-2 processing enzyme. ACS Chem. Biol. 5 (2010) 223-232. [PMID: 20025244]

3. Zhu, J., Hixon, M.S., Globisch, D., Kaufmann, G.F. and Janda, K.D. Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activation. J. Am. Chem. Soc. 135 (2013) 7827-7830. [PMID: 23672516]

[EC created 2015]

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