IUBMB Enzyme Nomenclature


Accepted name: 4-hydroxytryptamine kinase

Reaction: ATP + 4-hydroxytryptamine = ADP + 4-hydoxytryptamine 4-phosphate

For diagram of reaction click here

Glossary: psilocybin = 3-[2-(dimethylamino)ethyl]-1H-indol-4-yl phosphate

Other name(s): PsiK

Systematic name: ATP:4-hydroxytryptamine 4-phosphotransferase

Comments: Also acts on 4-hydroxy-L-tryptophan in vitro. Isolated from the fungus Psilocybe cubensis. Involved in the biosynthesis of the psychoactive compound psilocybin.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Fricke, J., Blei, F. and Hoffmeister, D. Enzymatic synthesis of psilocybin. Angew. Chem. Int. Ed. Engl. 56 (2017) 12352-12355.

[EC created 2017]

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