IUBMB Enzyme Nomenclature


Accepted name: NAD+ 3'-kinase

Reaction: ATP + NAD+ = ADP + 3'-NADP+

Glossary: 3'-NADP = nicotinamide adenine dinucleotide 3'-phosphate

Other name(s): AvrRxo1

Systematic name: ATP:NAD+ 3'-phosphotransferase

Comments: The enzyme, best characterized from the plant pathogenic bacterium Xanthomonas oryzae pv. oryzicola, is considered a bacterial type III effector. The product, 3'-NADP, is believed to enhance bacterial virulence on plants through manipulation of primary metabolic pathways. In vitro the enzyme is also active with nicotinate adenine dinucleotide (deamido-NAD).

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Schuebel, F., Rocker, A., Edelmann, D., Schessner, J., Brieke, C. and Meinhart, A. 3'-NADP and 3'-NAADP, Two Metabolites Formed by the Bacterial Type III Effector AvrRxo1. J. Biol. Chem. 291 (2016) 22868-22880. [PMID: 27621317]

2. Shidore, T., Broeckling, C.D., Kirkwood, J.S., Long, J.J., Miao, J., Zhao, B., Leach, J.E. and Triplett, L.R. The effector AvrRxo1 phosphorylates NAD in planta. PLoS Pathog. 13 (2017) e1006442. [PMID: 28628666]

[EC created 2022]

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