Reaction: ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate
For reaction pathway click here or click here.
Other name(s): mevalonate kinase (phosphorylating); mevalonate phosphokinase; mevalonic acid kinase; mevalonic kinase; mevalonate 5-phosphotransferase ; MVA kinase; ATP:mevalonate 5-phosphotransferase
Systematic name: ATP:(R)-mevalonate 5-phosphotransferase
Comments: CTP, GTP and UTP can also act as donors.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9026-52-2
References:
1. Hellig, H. and Popják, G. Studies on the biosynthesis of cholesterol. XIII. Phosphomevalonic kinase from liver. J. Lipid Res. 2 (1961) 235-243.
2. Levy, G.B. and Popják, G. Studies on the biosynthesis of cholesterol. 10. Mevalonic kinase from liver. Biochem. J. 75 (1960) 417-428.
3. Markley, K. and Smallman, E. Mevalonic kinase in rabbit liver. Biochim. Biophys. Acta 47 (1961) 327-335.
4. Tchen, T.T. Mevalonic kinase: purification and properties. J. Biol. Chem. 233 (1958) 1100-1103.