Reaction: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA
Other name(s): ATP:5'-dephosphopolynucleotide 5'-phosphatase; PNK; polynucleotide 5'-hydroxyl kinase (phosphorylating); 5'-hydroxyl polynucleotide kinase; 5'-hydroxyl polyribonucleotide kinase; 5'-hydroxyl RNA kinase; DNA 5'-hydroxyl kinase; DNA kinase; polynucleotide kinase; polynucleotide 5'-hydroxy-kinase
Systematic name: ATP:5'-dephosphopolynucleotide 5'-phosphotransferase
Comments: Also acts on 5'-dephospho-RNA 3'-mononucleotides.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37211-65-7
References:
1. Novogrodsky, A. and Hurwitz, J. The enzymatic phosphorylation of ribonucleic acid and deoxyribonucleic acid. I. Phosphorylation at 5'-hydroxyl termini. J. Biol. Chem. 241 (1966) 2923-2932. [PMID: 4287929]
2. Novogrodsky, A., Tal, M., Traub, A. and Hurwitz, J. The enzymatic phosphorylation of ribonucleic acid and deoxyribonucleic acid. II. Further properties of the 5'-hydroxyl polynucleotide kinase. J. Biol. Chem. 241 (1966) 2933-2943. [PMID: 4287930]