IUBMB Enzyme Nomenclature

EC 2.7.1.8

Accepted name: glucosamine kinase

Reaction: ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate

Glossary: D-glucosamine 6-phosphate = 2-amino-2-deoxy-D-glucose 6-phosphate

Other name(s): glucosamine kinase (phosphorylating); ATP:2-amino-2-deoxy-D-glucose-6-phosphotransferase; aminodeoxyglucose kinase; ATP:D-glucosamine phosphotransferase

Systematic name: ATP:D-glucosamine 6-phosphotransferase

Comments: The enzyme is specific for glucosamine and has only a minor activity with D-glucose. Two unrelated enzymes with this activity have been described. One type was studied in the bacterium Vibrio cholerae, where it participates in a chitin degradation pathway. The other type has been described from actinobacteria, where it is involved in the incorporation of environmental glucosamine into antibiotic biosynthesis pathways. cf. EC 2.7.1.147, ADP-specific glucose/glucosamine kinase.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9031-90-7

References:

1. Bueding, E. and MacKinnon, J.A. Hexokinases of Schistosoma mansoni. J. Biol. Chem. 215 (1955) 495-506. [PMID: 13242546]

2. Park, J.K., Wang, L.X. and Roseman, S. Isolation of a glucosamine-specific kinase, a unique enzyme of Vibrio cholerae. J. Biol. Chem. 277 (2002) 15573-15578. [PMID: 11850417]

3. Manso, J.A., Nunes-Costa, D., Macedo-Ribeiro, S., Empadinhas, N. and Pereira, P.J.B. Molecular fingerprints for a novel enzyme family in actinobacteria with glucosamine kinase activity. MBio 10 (2019) e00239-19 . [PMID: 31088917]

[EC 2.7.1.8 created 1961, modified 2014, modified 2020]


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