IUBMB Enzyme Nomenclature


Accepted name: kanamycin kinase

Reaction: ATP + kanamycin = ADP + kanamycin 3'-phosphate

Glossary: kanamycin

Other name(s): neomycin-kanamycin phosphotransferase;

kanamycin kinase (phosphorylating); neomycin phosphotransferase

Systematic name: ATP:kanamycin 3'-O-phosphotransferase

Comments: Also acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A. An enzyme from Pseudomonas aeruginosa also acts on butirosin.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 62213-36-9


1. Doi, O., Ogura, M., Tanaka, N. and Umezawa, H. Inactivation of kanamycin, neomycin, and streptomycin by enzymes obtained in cells of Pseudomonas aeruginosa. Appl. Microbiol. 16 (1968) 1276-1281. [PMID: 4970990]

2. Dolin, M.I. The Streptococcus faecalis oxidases for reduced diphosphopyridine nucleotide. III. Isolation and properties of a flavin peroxidase for reduced diphosphopyridine nucleotide. J. Biol. Chem. 225 (1957) 557-573.

[EC created 1976]

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