IUBMB Enzyme Nomenclature


Accepted name: [pyruvate, water dikinase] kinase

Reaction: ADP + [pyruvate, water dikinase] = AMP + [pyruvate, water dikinase] phosphate

Other name(s): PSRP (ambiguous); PEPS kinase

Systematic name: ADP:[pyruvate, water dikinase] phosphotransferase

Comments: The enzyme from the bacterium Escherichia coli is bifunctional and catalyses both the phosphorylation and dephosphorylation of EC, pyruvate, water dikinase. cf. EC, ([pyruvate, water dikinase] phosphate) phosphotransferase [1]. The enzyme is specific for a reaction intermediate form of EC, where it phosphorylates an active site histidine [1]. It has no activity toward EC pyruvate, phosphate dikinase (cf. EC, [pyruvate, phosphate dikinase] kinase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Burnell, J.N. Cloning and characterization of Escherichia coli DUF299: a bifunctional ADP-dependent kinase—Pi-dependent pyrophosphorylase from bacteria. BMC Biochem. 11 (2010) 1. [PMID: 20044937]

[EC created 2012]

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