IUBMB Enzyme Nomenclature


Accepted name: pyruvate, water dikinase

Reaction: ATP + pyruvate + H2O = AMP + phosphoenolpyruvate + phosphate

For diagram of reaction click here.

Other name(s): phosphoenolpyruvate synthase; pyruvate-water dikinase (phosphorylating); PEP synthetase; phosphoenolpyruvate synthase; phoephoenolpyruvate synthetase; phosphoenolpyruvic synthase; phosphopyruvate synthetase

Systematic name: ATP:pyruvate, water phosphotransferase

Comments: A manganese protein.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9013-09-6


1. Berman, K.M. and Cohn, M. Phosphoenolpyruvate synthetase of Escherichia coli. Purification, some properties, and the role of divalent metal ions. J. Biol. Chem. 245 (1970) 5309-5318 [PMID: 4319237]

2. Berman, K.M. and Cohn, M. Phosphoenolpyruvate synthetase. Partial reactions studied with adenosine triphosphate analogues and the inorganic phosphate-H218O exchange reaction. J. Biol. Chem. 245 (1970) 5319-5325. [PMID: 4319238]

3. Cooper, R.A. and Kornberg, H.L. Net formation of phosphoenolpyruvate from pyruvate by Escherichia coli. Biochim. Biophys. Acta 104 (1965) 618-620. [PMID: 5322808]

4. Cooper, R.A. and Kornberg, H.L. Phosphoenolpyruvate synthetase. Methods Enzymol. 13 (1969) 309-314.

[EC created 1976]

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