IUBMB Enzyme Nomenclature


Accepted name: phosphoenolpyruvate—protein phosphotransferase

Reaction: phosphoenolpyruvate + protein histidine = pyruvate + protein Nπ-phospho-L-histidine

Other names: phosphoenolpyruvate sugar phosphotransferase enzyme I; phosphopyruvate-protein factor phosphotransferase; phosphopyruvate-protein phosphotransferase; sugar-PEP phosphotransferase enzyme I; phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase

Systematic name: phosphoenolpyruvate:protein-L-histidine Nπ-phosphotransferase

Comments: Enzyme I of the phosphotransferase system (cf. EC protein-Nπ-phosphohistidine—sugar phosphotransferase). Acts only on histidine residues in specific phosphocarrier proteins of low molecular mass (9.5 kDa) involved in bacterial sugar transport. A similar reaction, where the protein is the enzyme EC pyruvate, water dikinase, is part of the mechanism of that enzyme.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37278-17-4


1. Postma, P.W. and Roseman, S. The bacterial phosphoenolpyruvate: sugar phosphotransferase system. Biochim. Biophys. Acta 457 (1976) 213-257. [PMID: 187249]

[EC created 1972]

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