IUBMB Enzyme Nomenclature


Accepted name: ribose 1,5-bisphosphate phosphokinase

Reaction: ATP + α-D-ribose 1,5-bisphosphate = ADP + 5-phospho-α-D-ribose 1-diphosphate

For diagram of reaction click here.

Glossary: PRPP = 5-phospho-α-D-ribose 1-diphosphate

Other name(s): ribose 1,5-bisphosphokinase; PhnN; ATP:ribose-1,5-bisphosphate phosphotransferase

Systematic name: ATP:α-D-ribose-1,5-bisphosphate phosphotransferase

Comments: This enzyme, found in NAD supression mutants of Escherichia coli, synthesizes 5-phospho-α-D-ribose 1-diphosphate (PRPP) without the participation of EC, ribose-phosphate diphosphokinase. Ribose, ribose 1-phosphate and ribose 5-phosphate are not substrates, and GTP cannot act as a phosphate donor.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Hove-Jensen, B., Rosenkrantz, T.J., Haldimann, A. and Wanner, B.L. Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways. J. Bacteriol. 185 (2003) 2793-2801. [PMID: 12700258]

[EC created 2006]

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