IUBMB Enzyme Nomenclature


Accepted name: (+)-germacrene D synthase

Reaction: (2E,6E)-farnesyl diphosphate = (+)-germacrene D + diphosphate

For diagram of reaction click here.

Glossary: (+)-germacrene D = (1E,6E,8R)-1-methyl-5-methylidene-8-(propan-2-yl)cyclodeca-1,6-diene

Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-germacrene-D-forming]

Comments: Requires Mg2+, Mn2+, Ni2+ or Co2+. The formation of (+)-germacrene D involves a 1,2-hydride shift whereas for (–)-germacrene D there is a 1,3-hydride shift (see EC

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Picaud, S., Olsson, M.E., Brodelius, M. and Brodelius, P.E. Cloning, expression, purification and characterization of recombinant (+)-germacrene D synthase from Zingiber officinale. Arch. Biochem. Biophys. 452 (2006) 17-28. [PMID: 16839518]

[EC created 2011]

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