IUBMB Enzyme Nomenclature


Accepted name: P-type Na+ transporter

Reaction: ATP + H2O + Na+[side 1] = ADP + phosphate + Na+[side 2]

Other name(s): Na+-exporting ATPase (ambiguous); ENA1 (gene name); ENA2 (gene name); ENA5 (gene name)

Systematic name: ATP phosphohydrolase (P-type, Na+-exporting)

Comments: A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme from yeast is involved in the efflux of Na+, with one ion being exported per ATP hydrolysed. Some forms can also export Li+ ions. cf. EC, Na+-transporting two-sector ATPase and EC, ABC-type Na+ transporter.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Wieland, J., Nitsche, A.M., Strayle, J., Steiner, H. and Rudolph, H.K. The PMR2 gene cluster encodes functionally distinct isoforms of a putative Na+ pump in the yeast plasma membrane. EMBO J. 14 (1995) 3870-3882. [PMID: 7664728]

2. Catty, P., de Kerchove d'Exaerde, A. and Goffeau, A. The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases. FEBS Lett. 409 (1997) 325-332. [PMID: 9224683]

3. Benito, B., Quintero, F.J. and Rodriguez-Navarro, A. Overexpression of the sodium ATPase of Saccharomyces cerevisiae: conditions for phosphorylation from ATP and Pi. Biochim. Biophys. Acta 1328 (1997) 214-226. [PMID: 9315618]

4. Saier, M.H., Jr. Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya. Adv. Microb. Physiol. 40 (1998) 81-136. [PMID: 9889977]

[EC created 2000, as EC, modified 2001, transferred 20018 to EC]

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